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Leishmanicidal activity of the crude extract, fractions and major piperidine alkaloids from the flowers of Senna spectabilis.
de Albuquerque Melo GM, Silva MC, Guimarães TP, Pinheiro KM, da Matta CB, de Queiroz AC, Pivatto M, Bolzani Vda S, Alexandre-Moreira MS, Viegas C Jr. de Albuquerque Melo GM, et al. Among authors: bolzani vda s. Phytomedicine. 2014 Feb 15;21(3):277-81. doi: 10.1016/j.phymed.2013.09.024. Epub 2013 Nov 1. Phytomedicine. 2014. PMID: 24188737
Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.
Pereira RM, Ferreira-Silva GÁ, Pivatto M, Santos Lde Á, Bolzani Vda S, Chagas de Paula DA, Oliveira JC, Viegas Júnior C, Ionta M. Pereira RM, et al. Among authors: bolzani vda s. Toxicol In Vitro. 2016 Mar;31:86-92. doi: 10.1016/j.tiv.2015.11.018. Epub 2015 Nov 23. Toxicol In Vitro. 2016. PMID: 26616281
Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.
Passalacqua TG, Dutra LA, de Almeida L, Velásquez AM, Torres FA, Yamasaki PR, dos Santos MB, Regasini LO, Michels PA, Bolzani Vda S, Graminha MA. Passalacqua TG, et al. Among authors: bolzani vda s. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3342-5. doi: 10.1016/j.bmcl.2015.05.072. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26055530
The 2',4'-dihydroxychalcone could be explored to develop new inhibitors against the glycerol-3-phosphate dehydrogenase from Leishmania species.
Passalacqua TG, Torres FA, Nogueira CT, de Almeida L, Del Cistia ML, dos Santos MB, Dutra LA, Bolzani VS, Regasini LO, Graminha MA, Marchetto R, Zottis A. Passalacqua TG, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3564-8. doi: 10.1016/j.bmcl.2015.06.085. Epub 2015 Jun 30. Bioorg Med Chem Lett. 2015. PMID: 26169126
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins.
Araújo ÉJ, De Oliveira GA, de Sousa LQ, Bolzani Vda S, Cavalheiro AJ, Tome Ada R, Peron AP, dos Santos AG, Citó AM, Pessoa C, de Freitas RM, Ferreira PM. Araújo ÉJ, et al. Among authors: bolzani vda s. An Acad Bras Cienc. 2015 Sep;87(3):1791-807. doi: 10.1590/0001-3765201520150149. Epub 2015 Sep 15. An Acad Bras Cienc. 2015. PMID: 26375017 Free article.
67 results