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A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
Keurulainen L, Vahermo M, Puente-Felipe M, Sandoval-Izquierdo E, Crespo-Fernández B, Guijarro-López L, Huertas-Valentín L, de las Heras-Dueña L, Leino TO, Siiskonen A, Ballell-Pages L, Sanz LM, Castañeda-Casado P, Jiménez-Díaz MB, Martínez-Martínez MS, Viera S, Kiuru P, Calderón F, Yli-Kauhaluoma J. Keurulainen L, et al. J Med Chem. 2015 Jun 11;58(11):4573-80. doi: 10.1021/acs.jmedchem.5b00114. Epub 2015 May 19. J Med Chem. 2015. PMID: 25906200
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.
Figueiredo J, Serrano JL, Cavalheiro E, Keurulainen L, Yli-Kauhaluoma J, Moreira VM, Ferreira S, Domingues FC, Silvestre S, Almeida P. Figueiredo J, et al. Among authors: keurulainen l. Eur J Med Chem. 2018 Jan 1;143:829-842. doi: 10.1016/j.ejmech.2017.11.070. Epub 2017 Nov 27. Eur J Med Chem. 2018. PMID: 29223098 Free article.
Non-leaching, Highly Biocompatible Nanocellulose Surfaces That Efficiently Resist Fouling by Bacteria in an Artificial Dermis Model.
Hassan G, Forsman N, Wan X, Keurulainen L, Bimbo LM, Stehl S, van Charante F, Chrubasik M, Prakash AS, Johansson LS, Mullen DC, Johnston BF, Zimmermann R, Werner C, Yli-Kauhaluoma J, Coenye T, Saris PEJ, Österberg M, Moreira VM. Hassan G, et al. Among authors: keurulainen l. ACS Appl Bio Mater. 2020 Jul 20;3(7):4095-4108. doi: 10.1021/acsabm.0c00203. Epub 2020 Jun 26. ACS Appl Bio Mater. 2020. PMID: 35025484 Free article.