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Page 1
Sphingolipids in Major Depression.
Jernigan PL, Hoehn RS, Grassmé H, Edwards MJ, Müller CP, Kornhuber J, Gulbins E. Jernigan PL, et al. Among authors: edwards mj. Neurosignals. 2015;23(1):49-58. doi: 10.1159/000442603. Epub 2015 Dec 19. Neurosignals. 2015. PMID: 26684792 Free article. Review.
Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.
Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Gulbins A, et al. Among authors: edwards mj. Mol Psychiatry. 2018 Dec;23(12):2324-2346. doi: 10.1038/s41380-018-0090-9. Epub 2018 Jul 23. Mol Psychiatry. 2018. PMID: 30038230 Free PMC article.
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Carpinteiro A, Edwards MJ, Hoffmann M, Kochs G, Gripp B, Weigang S, Adams C, Carpinteiro E, Gulbins A, Keitsch S, Sehl C, Soddemann M, Wilker B, Kamler M, Bertsch T, Lang KS, Patel S, Wilson GC, Walter S, Hengel H, Pöhlmann S, Lang PA, Kornhuber J, Becker KA, Ahmad SA, Fassbender K, Gulbins E. Carpinteiro A, et al. Among authors: edwards mj. Cell Rep Med. 2020 Nov 17;1(8):100142. doi: 10.1016/j.xcrm.2020.100142. Epub 2020 Oct 29. Cell Rep Med. 2020. PMID: 33163980 Free PMC article.
Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice.
Schumacher F, Edwards MJ, Mühle C, Carpinteiro A, Wilson GC, Wilker B, Soddemann M, Keitsch S, Scherbaum N, Müller BW, Lang UE, Linnemann C, Kleuser B, Müller CP, Kornhuber J, Gulbins E. Schumacher F, et al. Among authors: edwards mj. J Biol Chem. 2022 Aug;298(8):102185. doi: 10.1016/j.jbc.2022.102185. Epub 2022 Jun 24. J Biol Chem. 2022. PMID: 35753355 Free PMC article.
Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma.
Schumacher F, Carpinteiro A, Edwards MJ, Wilson GC, Keitsch S, Soddemann M, Wilker B, Kleuser B, Becker KA, Müller CP, Kornhuber J, Gulbins E. Schumacher F, et al. Among authors: edwards mj. J Mol Med (Berl). 2022 Oct;100(10):1493-1508. doi: 10.1007/s00109-022-02250-y. Epub 2022 Aug 31. J Mol Med (Berl). 2022. PMID: 36045177 Free PMC article.
Regulation of hematogenous tumor metastasis by acid sphingomyelinase.
Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Požgajovà M, Schmid KW, Adams C, Müller S, Kleuser B, Edwards MJ, Grassmé H, Helfrich I, Gulbins E. Carpinteiro A, et al. Among authors: edwards mj. EMBO Mol Med. 2015 Jun;7(6):714-34. doi: 10.15252/emmm.201404571. EMBO Mol Med. 2015. PMID: 25851537 Free PMC article.
1,045 results