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Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.
J Med Chem. 2015 Jul 9;58(13):5189-207. doi: 10.1021/acs.jmedchem.5b00183. Epub 2015 May 31.
J Med Chem. 2015.
PMID: 25970324
Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials throughout the supply chain.
Chaves MK, Kelly RC, Milne JE, Burke SE.
Chaves MK, et al.
Pharm Dev Technol. 2022 Jun;27(5):511-524. doi: 10.1080/10837450.2022.2084105. Epub 2022 Jun 21.
Pharm Dev Technol. 2022.
PMID: 35702831
Free article.
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Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction.
Wang W, Zhang L, Battiprolu PK, Fukushima A, Nguyen K, Milner K, Gupta A, Altamimi T, Byrne N, Mori J, Alrob OA, Wagg C, Fillmore N, Wang SH, Liu DM, Fu A, Lu JY, Chaves M, Motani A, Ussher JR, Reagan JD, Dyck JRB, Lopaschuk GD.
Wang W, et al.
JACC Basic Transl Sci. 2019 Jun 24;4(3):385-400. doi: 10.1016/j.jacbts.2019.02.003. eCollection 2019 Jun.
JACC Basic Transl Sci. 2019.
PMID: 31312761
Free PMC article.
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