Roose JP - Search Results

1

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.

Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. Depeille P, et al. Among authors: roose jp. Nat Cell Biol. 2015 Jun;17(6):804-15. doi: 10.1038/ncb3175. Epub 2015 May 25. Nat Cell Biol. 2015. PMID: 26005835 Free PMC article.

2

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.

Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A. Roose JP, et al. Mol Cell Biol. 2005 Jun;25(11):4426-41. doi: 10.1128/MCB.25.11.4426-4441.2005. Mol Cell Biol. 2005. PMID: 15899849 Free PMC article.

3

Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.

Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A. Roose JP, et al. Mol Cell Biol. 2007 Apr;27(7):2732-45. doi: 10.1128/MCB.01882-06. Epub 2007 Feb 5. Mol Cell Biol. 2007. PMID: 17283063 Free PMC article.

4

Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. Das J, et al. Among authors: roose jp. Cell. 2009 Jan 23;136(2):337-51. doi: 10.1016/j.cell.2008.11.051. Cell. 2009. PMID: 19167334 Free PMC article.

5

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.

Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K. Lauchle JO, et al. Among authors: roose jp. Nature. 2009 Sep 17;461(7262):411-4. doi: 10.1038/nature08279. Epub 2009 Sep 2. Nature. 2009. PMID: 19727076 Free PMC article.

6

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.

Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. Limnander A, et al. Among authors: roose jp. Nat Immunol. 2011 May;12(5):425-33. doi: 10.1038/ni.2016. Epub 2011 Mar 27. Nat Immunol. 2011. PMID: 21441934 Free PMC article.

7

Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.

Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. Markegard E, et al. Among authors: roose jp. PLoS One. 2011;6(9):e25540. doi: 10.1371/journal.pone.0025540. Epub 2011 Sep 26. PLoS One. 2011. PMID: 21966541 Free PMC article.

8

Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.

Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP. Hartzell C, et al. Among authors: roose jp. Sci Signal. 2013 Mar 26;6(268):ra21. doi: 10.1126/scisignal.2003848. Sci Signal. 2013. PMID: 23532335 Free PMC article.

9

Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.

Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP. Jun JE, et al. Among authors: roose jp. Mol Cell Biol. 2013 Jun;33(12):2470-84. doi: 10.1128/MCB.01593-12. Epub 2013 Apr 15. Mol Cell Biol. 2013. PMID: 23589333 Free PMC article.

10

PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras.

Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. Diaz-Flores E, et al. Among authors: roose jp. Sci Signal. 2013 Dec 3;6(304):ra105. doi: 10.1126/scisignal.2004125. Sci Signal. 2013. PMID: 24300897 Free PMC article.

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