Oh YT - Search Results

1

The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5.

Han B, Yao W, Oh YT, Tong JS, Li S, Deng J, Yue P, Khuri FR, Sun SY. Han B, et al. Among authors: oh yt. Oncotarget. 2015 Jul 10;6(19):17532-42. doi: 10.18632/oncotarget.3947. Oncotarget. 2015. PMID: 26009898 Free PMC article.

2

ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1.

Oh YT, Liu X, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY. Oh YT, et al. J Biol Chem. 2010 Dec 31;285(53):41310-9. doi: 10.1074/jbc.M110.153775. Epub 2010 Nov 2. J Biol Chem. 2010. PMID: 21044953 Free PMC article.

3

c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.

Fu L, Lin YD, Elrod HA, Yue P, Oh Y, Li B, Tao H, Chen GZ, Shin DM, Khuri FR, Sun SY. Fu L, et al. Mol Cancer. 2010 Dec 20;9:315. doi: 10.1186/1476-4598-9-315. Mol Cancer. 2010. PMID: 21172010 Free PMC article.

4

Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling.

Oh YT, Yue P, Zhou W, Balko JM, Black EP, Owonikoko TK, Khuri FR, Sun SY. Oh YT, et al. J Biol Chem. 2012 Jan 2;287(1):257-267. doi: 10.1074/jbc.M111.304006. Epub 2011 Nov 7. J Biol Chem. 2012. PMID: 22065586 Free PMC article.

5

Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling.

Oh YT, Yue P, Wang D, Tong JS, Chen ZG, Khuri FR, Sun SY. Oh YT, et al. Oncotarget. 2015 Dec 1;6(38):41324-38. doi: 10.18632/oncotarget.5847. Oncotarget. 2015. PMID: 26510914 Free PMC article.

6

Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells.

Oh YT, Deng J, Yue P, Sun SY. Oh YT, et al. Sci Rep. 2016 May 25;6:26803. doi: 10.1038/srep26803. Sci Rep. 2016. PMID: 27222248 Free PMC article.

7

Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.

Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY. Shi P, et al. Among authors: oh yt. Cancer Lett. 2016 Oct 1;380(2):494-504. doi: 10.1016/j.canlet.2016.07.021. Epub 2016 Jul 19. Cancer Lett. 2016. PMID: 27450722

8

Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK Inhibition.

Yao W, Oh YT, Deng J, Yue P, Deng L, Huang H, Zhou W, Sun SY. Yao W, et al. Among authors: oh yt. J Biol Chem. 2016 Oct 7;291(41):21694-21702. doi: 10.1074/jbc.M116.738302. Epub 2016 Aug 30. J Biol Chem. 2016. PMID: 27576686 Free PMC article.

9

DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion.

Oh YT, Yue P, Sun SY. Oh YT, et al. Cell Commun Signal. 2017 May 8;15(1):18. doi: 10.1186/s12964-017-0174-1. Cell Commun Signal. 2017. PMID: 28482915 Free PMC article.

10

Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation.

Shi P, Oh YT, Deng L, Zhang G, Qian G, Zhang S, Ren H, Wu G, Legendre B Jr, Anderson E, Ramalingam SS, Owonikoko TK, Chen M, Sun SY. Shi P, et al. Among authors: oh yt. Clin Cancer Res. 2017 Nov 1;23(21):6567-6579. doi: 10.1158/1078-0432.CCR-17-1574. Epub 2017 Aug 1. Clin Cancer Res. 2017. PMID: 28765329 Free PMC article.

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