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Page 1
Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.
Anighoro A, Graziani D, Bettinelli I, Cilia A, De Toma C, Longhi M, Mangiarotti F, Menegon S, Pirona L, Poggesi E, Riva C, Rastelli G. Anighoro A, et al. Among authors: cilia a. Bioorg Med Chem. 2015 Jul 1;23(13):3040-58. doi: 10.1016/j.bmc.2015.05.008. Epub 2015 May 12. Bioorg Med Chem. 2015. PMID: 26014480
Discovery of a new series of 5-HT1A receptor agonists.
Franchini S, Prandi A, Sorbi C, Tait A, Baraldi A, Angeli P, Buccioni M, Cilia A, Poggesi E, Fossa P, Brasili L. Franchini S, et al. Among authors: cilia a. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2017-20. doi: 10.1016/j.bmcl.2010.01.030. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20185311
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.
Franchini S, Prandi A, Baraldi A, Sorbi C, Tait A, Buccioni M, Marucci G, Cilia A, Pirona L, Fossa P, Cichero E, Brasili L. Franchini S, et al. Among authors: cilia a. Eur J Med Chem. 2010 Sep;45(9):3740-51. doi: 10.1016/j.ejmech.2010.05.023. Epub 2010 May 15. Eur J Med Chem. 2010. PMID: 20605276
Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists of α1-adrenoceptor.
Silva RO, de Oliveira AS, Nunes Lemes LF, de Camargo Nascente L, Coelho do Nascimento Nogueira P, Silveira ER, Brand GD, Vistoli G, Cilia A, Poggesi E, Buccioni M, Marucci G, Bolognesi ML, Romeiro LAS. Silva RO, et al. Among authors: cilia a. Eur J Med Chem. 2016 Oct 21;122:601-610. doi: 10.1016/j.ejmech.2016.06.052. Epub 2016 Jun 30. Eur J Med Chem. 2016. PMID: 27448917
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes.
Del Bello F, Bonifazi A, Giannella M, Giorgioni G, Piergentili A, Petrelli R, Cifani C, Micioni Di Bonaventura MV, Keck TM, Mazzolari A, Vistoli G, Cilia A, Poggesi E, Matucci R, Quaglia W. Del Bello F, et al. Among authors: cilia a. Eur J Med Chem. 2017 Jan 5;125:233-244. doi: 10.1016/j.ejmech.2016.09.026. Epub 2016 Sep 9. Eur J Med Chem. 2017. PMID: 27662034
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.
Franchini S, Manasieva LI, Sorbi C, Battisti UM, Fossa P, Cichero E, Denora N, Iacobazzi RM, Cilia A, Pirona L, Ronsisvalle S, Aricò G, Brasili L. Franchini S, et al. Among authors: cilia a. Eur J Med Chem. 2017 Jan 5;125:435-452. doi: 10.1016/j.ejmech.2016.09.050. Epub 2016 Sep 17. Eur J Med Chem. 2017. PMID: 27689727 Free article.
48 results