Lu D - Search Results

1

Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.

Hobson A, Draney C, Stratford A, Becker TC, Lu D, Arlotto M, Tessem JS. Hobson A, et al. Among authors: lu d. Islets. 2015;7(1):e1027854. doi: 10.1080/19382014.2015.1027854. Epub 2015 Jun 1. Islets. 2015. PMID: 26030060 Free PMC article.

2

Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.

Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. Tessem JS, et al. Among authors: lu d. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24. Proc Natl Acad Sci U S A. 2014. PMID: 24706823 Free PMC article.

3

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.

Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB. Schisler JC, et al. Among authors: lu d. Mol Cell Biol. 2008 May;28(10):3465-76. doi: 10.1128/MCB.01791-07. Epub 2008 Mar 17. Mol Cell Biol. 2008. PMID: 18347054 Free PMC article.

4

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB. Schisler JC, et al. Among authors: lu d. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. doi: 10.1073/pnas.0502168102. Epub 2005 May 9. Proc Natl Acad Sci U S A. 2005. PMID: 15883383 Free PMC article.

5

Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.

Ronnebaum SM, Joseph JW, Ilkayeva O, Burgess SC, Lu D, Becker TC, Sherry AD, Newgard CB. Ronnebaum SM, et al. Among authors: lu d. J Biol Chem. 2008 May 23;283(21):14248-56. doi: 10.1074/jbc.M800119200. Epub 2008 Apr 1. J Biol Chem. 2008. PMID: 18381287 Free PMC article.

6

Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion.

Zhang GF, Jensen MV, Gray SM, El K, Wang Y, Lu D, Becker TC, Campbell JE, Newgard CB. Zhang GF, et al. Among authors: lu d. Cell Metab. 2021 Apr 6;33(4):804-817.e5. doi: 10.1016/j.cmet.2020.11.020. Epub 2020 Dec 14. Cell Metab. 2021. PMID: 33321098 Free PMC article.

7

The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.

Odegaard ML, Joseph JW, Jensen MV, Lu D, Ilkayeva O, Ronnebaum SM, Becker TC, Newgard CB. Odegaard ML, et al. Among authors: lu d. J Biol Chem. 2010 May 28;285(22):16530-7. doi: 10.1074/jbc.M109.092593. Epub 2010 Mar 31. J Biol Chem. 2010. PMID: 20356834 Free PMC article.

8

Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.

Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB. Jensen MV, et al. Among authors: lu d. J Biol Chem. 2006 Aug 4;281(31):22342-22351. doi: 10.1074/jbc.M604350200. Epub 2006 Jun 1. J Biol Chem. 2006. PMID: 16740637 Free article.

9

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.

Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV. Ronnebaum SM, et al. Among authors: lu d. J Biol Chem. 2006 Oct 13;281(41):30593-602. doi: 10.1074/jbc.M511908200. Epub 2006 Aug 15. J Biol Chem. 2006. PMID: 16912049 Free article.

10

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.

Hohmeier HE, Zhang L, Taylor B, Stephens S, Lu D, McNamara P, Laffitte B, Newgard CB. Hohmeier HE, et al. Among authors: lu d. PLoS One. 2020 Mar 16;15(3):e0224344. doi: 10.1371/journal.pone.0224344. eCollection 2020. PLoS One. 2020. PMID: 32176701 Free PMC article.

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