Kukushkin N - Search Results

1

Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates.

Sandu C, Chandramouli N, Glickman JF, Molina H, Kuo CL, Kukushkin N, Goldberg AL, Steller H. Sandu C, et al. Among authors: kukushkin n. J Cell Mol Med. 2015 Sep;19(9):2181-92. doi: 10.1111/jcmm.12602. Epub 2015 May 30. J Cell Mol Med. 2015. PMID: 26033448 Free PMC article.

2

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.

Lokireddy S, Kukushkin NV, Goldberg AL. Lokireddy S, et al. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7176-85. doi: 10.1073/pnas.1522332112. Epub 2015 Dec 15. Proc Natl Acad Sci U S A. 2015. PMID: 26669444 Free PMC article.

3

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL, Duff KE. Myeku N, et al. Among authors: kukushkin nv. Nat Med. 2016 Jan;22(1):46-53. doi: 10.1038/nm.4011. Epub 2015 Dec 21. Nat Med. 2016. PMID: 26692334 Free PMC article.

4

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

Besche HC, Sha Z, Kukushkin NV, Peth A, Hock EM, Kim W, Gygi S, Gutierrez JA, Liao H, Dick L, Goldberg AL. Besche HC, et al. EMBO J. 2014 May 16;33(10):1159-76. doi: 10.1002/embj.201386906. Epub 2014 May 8. EMBO J. 2014. PMID: 24811749 Free PMC article.

5

Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs.

Peth A, Kukushkin N, Bossé M, Goldberg AL. Peth A, et al. Among authors: kukushkin n. J Biol Chem. 2013 Mar 15;288(11):7781-7790. doi: 10.1074/jbc.M112.441907. Epub 2013 Jan 22. J Biol Chem. 2013. PMID: 23341450 Free PMC article.

6

Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins.

Alonzi DS, Kukushkin NV, Allman SA, Hakki Z, Williams SJ, Pierce L, Dwek RA, Butters TD. Alonzi DS, et al. Cell Mol Life Sci. 2013 Aug;70(15):2799-814. doi: 10.1007/s00018-013-1304-6. Epub 2013 Mar 16. Cell Mol Life Sci. 2013. PMID: 23503623 Free PMC article.

7

Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells.

Butters TD, Alonzi DS, Kukushkin NV, Ren Y, Blériot Y. Butters TD, et al. Glycoconj J. 2009 Dec;26(9):1109-16. doi: 10.1007/s10719-009-9231-3. Glycoconj J. 2009. PMID: 19234785

8

Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase.

Kukushkin NV, Alonzi DS, Dwek RA, Butters TD. Kukushkin NV, et al. Biochem J. 2011 Aug 15;438(1):133-42. doi: 10.1042/BJ20110186. Biochem J. 2011. PMID: 21585340

9

Restricted processing of glycans by endomannosidase in mammalian cells.

Kukushkin NV, Easthope IS, Alonzi DS, Butters TD. Kukushkin NV, et al. Glycobiology. 2012 Oct;22(10):1282-8. doi: 10.1093/glycob/cws088. Epub 2012 May 28. Glycobiology. 2012. PMID: 22641772

10

Non-specific accumulation of glycosphingolipids in GNE myopathy.

Patzel KA, Yardeni T, Le Poëc-Celic E, Leoyklang P, Dorward H, Alonzi DS, Kukushkin NV, Xu B, Zhang Y, Sollogoub M, Blériot Y, Gahl WA, Huizing M, Butters TD. Patzel KA, et al. J Inherit Metab Dis. 2014 Mar;37(2):297-308. doi: 10.1007/s10545-013-9655-6. Epub 2013 Oct 18. J Inherit Metab Dis. 2014. PMID: 24136589 Free PMC article.

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