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Longer duration of B cell depletion is associated with better outcome.
Dias SS, Rodriguez-Garcia V, Nguyen H, Pericleous C, Isenberg D. Dias SS, et al. Among authors: pericleous c. Rheumatology (Oxford). 2015 Oct;54(10):1876-81. doi: 10.1093/rheumatology/kev036. Epub 2015 Jun 3. Rheumatology (Oxford). 2015. PMID: 26044042
In vivo inhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of beta2-glycoprotein I: proof of concept.
Ioannou Y, Romay-Penabad Z, Pericleous C, Giles I, Papalardo E, Vargas G, Shilagard T, Latchman DS, Isenberg DA, Rahman A, Pierangeli S. Ioannou Y, et al. Among authors: pericleous c. J Thromb Haemost. 2009 May;7(5):833-42. doi: 10.1111/j.1538-7836.2009.03316.x. Epub 2009 Feb 12. J Thromb Haemost. 2009. PMID: 19220729 Free article.
Thrombin binding predicts the effects of sequence changes in a human monoclonal antiphospholipid antibody on its in vivo biologic actions.
Giles I, Pericleous C, Liu X, Ehsanullah J, Clarke L, Brogan P, Newton-West M, Swerlick R, Lambrianides A, Chen P, Latchman D, Isenberg D, Pierangeli S, Rahman A. Giles I, et al. Among authors: pericleous c. J Immunol. 2009 Apr 15;182(8):4836-43. doi: 10.4049/jimmunol.0804241. J Immunol. 2009. PMID: 19342662 Free article.
Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways.
Lambrianides A, Carroll CJ, Pierangeli SS, Pericleous C, Branch W, Rice J, Latchman DS, Townsend P, Isenberg DA, Rahman A, Giles IP. Lambrianides A, et al. Among authors: pericleous c. J Immunol. 2010 Jun 15;184(12):6622-8. doi: 10.4049/jimmunol.0902765. Epub 2010 May 17. J Immunol. 2010. PMID: 20483743 Free PMC article.
Interactions of human monoclonal and polyclonal antiphospholipid antibodies with serine proteases involved in hemostasis.
Lambrianides A, Turner-Stokes T, Pericleous C, Ehsanullah J, Papadimitraki E, Poulton K, Ioannou Y, Lawrie A, Mackie I, Chen P, Latchman D, Isenberg D, Rahman A, Giles I. Lambrianides A, et al. Among authors: pericleous c. Arthritis Rheum. 2011 Nov;63(11):3512-21. doi: 10.1002/art.30525. Arthritis Rheum. 2011. PMID: 21739425 Free PMC article.
Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis.
Pericleous C, Ruiz-Limón P, Romay-Penabad Z, Marín AC, Garza-Garcia A, Murfitt L, Driscoll PC, Latchman DS, Isenberg DA, Giles I, Ioannou Y, Rahman A, Pierangeli SS. Pericleous C, et al. Rheumatology (Oxford). 2015 Apr;54(4):722-7. doi: 10.1093/rheumatology/keu360. Epub 2014 Sep 30. Rheumatology (Oxford). 2015. PMID: 25273993 Free PMC article.
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