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IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951.
Clappier E, Grardel N, Bakkus M, Rapion J, De Moerloose B, Kastner P, Caye A, Vivent J, Costa V, Ferster A, Lutz P, Mazingue F, Millot F, Plantaz D, Plat G, Plouvier E, Poirée M, Sirvent N, Uyttebroeck A, Yakouben K, Girard S, Dastugue N, Suciu S, Benoit Y, Bertrand Y, Cavé H; European Organisation for Research and Treatment of Cancer, Children's Leukemia Group (EORTC-CLG). Clappier E, et al. Among authors: kastner p. Leukemia. 2015 Nov;29(11):2154-61. doi: 10.1038/leu.2015.134. Epub 2015 Jun 8. Leukemia. 2015. PMID: 26050650 Clinical Trial.
Genetic inactivation of Ikaros is a rare event in human T-ALL.
Marçais A, Jeannet R, Hernandez L, Soulier J, Sigaux F, Chan S, Kastner P. Marçais A, et al. Among authors: kastner p. Leuk Res. 2010 Apr;34(4):426-9. doi: 10.1016/j.leukres.2009.09.012. Epub 2009 Sep 30. Leuk Res. 2010. PMID: 19796813
Large deletions of the 5' region of IKZF1 lead to haploinsufficiency in B-cell precursor acute lymphoblastic leukaemia.
Morel G, Deau MC, Simand C, Caye-Eude A, Arfeuille C, Ittel A, Miguet L, Mauvieux L, Herbrecht R, Paillard C, Strullu M, Cavé H, Chan S, Kastner P, Heizmann B. Morel G, et al. Among authors: kastner p. Br J Haematol. 2019 Sep;186(5):e155-e159. doi: 10.1111/bjh.15994. Epub 2019 May 30. Br J Haematol. 2019. PMID: 31148164 Free article. No abstract available.
Ikaros deficiency is associated with aggressive BCR-ABL1 B-cell precursor acute lymphoblastic leukemia independent of the lineage and developmental origin.
Simand C, Keime C, Cayé A, Arfeuille C, Passet M, Kim R, Cavé H, Clappier E, Kastner P, Chan S, Heizmann B. Simand C, et al. Among authors: kastner p. Haematologica. 2022 Jan 1;107(1):316-320. doi: 10.3324/haematol.2021.279125. Haematologica. 2022. PMID: 34587720 Free PMC article. No abstract available.
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.
Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P. Jeannet R, et al. Among authors: kastner p. Blood. 2010 Dec 16;116(25):5443-54. doi: 10.1182/blood-2010-05-286658. Epub 2010 Sep 9. Blood. 2010. PMID: 20829372 Free PMC article.
281 results