Ehlert FJ - Search Results

1

Functional studies cast light on receptor states.

Ehlert FJ. Ehlert FJ. Trends Pharmacol Sci. 2015 Sep;36(9):596-604. doi: 10.1016/j.tips.2015.05.008. Epub 2015 Jun 26. Trends Pharmacol Sci. 2015. PMID: 26123416 Free PMC article. Review.

2

Estimation of ligand affinity constants for receptor states in functional studies involving the allosteric modulation of G protein-coupled receptors: implications for ligand bias.

Ehlert FJ, Griffin MT. Ehlert FJ, et al. J Pharmacol Toxicol Methods. 2014 May-Jun;69(3):253-79. doi: 10.1016/j.vascn.2014.01.002. Epub 2014 Jan 13. J Pharmacol Toxicol Methods. 2014. PMID: 24434717 Free PMC article.

3

Estimation of the receptor-state affinity constants of ligands in functional studies using wild type and constitutively active mutant receptors: Implications for estimation of agonist bias.

Ehlert FJ, Stein RS. Ehlert FJ, et al. J Pharmacol Toxicol Methods. 2017 Jan-Feb;83:94-106. doi: 10.1016/j.vascn.2016.09.007. Epub 2016 Oct 7. J Pharmacol Toxicol Methods. 2017. PMID: 27725245 Free PMC article.

4

Cooperativity Has Empirical and Ultimate Levels of Explanation.

Ehlert FJ. Ehlert FJ. Trends Pharmacol Sci. 2016 Aug;37(8):620-623. doi: 10.1016/j.tips.2016.06.001. Epub 2016 Jun 27. Trends Pharmacol Sci. 2016. PMID: 27364140 Free article.

5

Analysis of agonism and inverse agonism in functional assays with constitutive activity: estimation of orthosteric ligand affinity constants for active and inactive receptor states.

Ehlert FJ, Suga H, Griffin MT. Ehlert FJ, et al. J Pharmacol Exp Ther. 2011 Aug;338(2):671-86. doi: 10.1124/jpet.111.179309. Epub 2011 May 16. J Pharmacol Exp Ther. 2011. PMID: 21576379 Free PMC article.

6

A kinetic model of GPCRs: analysis of G protein activity, occupancy, coupling and receptor-state affinity constants.

Stein RS, Ehlert FJ. Stein RS, et al. Among authors: ehlert fj. J Recept Signal Transduct Res. 2015;35(4):269-83. doi: 10.3109/10799893.2014.975250. Epub 2014 Oct 29. J Recept Signal Transduct Res. 2015. PMID: 25353707

7

Quantifying agonist activity at G protein-coupled receptors.

Ehlert FJ, Suga H, Griffin MT. Ehlert FJ, et al. J Vis Exp. 2011 Dec 26;(58):e3179. doi: 10.3791/3179. J Vis Exp. 2011. PMID: 22231636 Free PMC article.

8

Analysis of Biased Agonism.

Ehlert FJ. Ehlert FJ. Prog Mol Biol Transl Sci. 2018;160:63-104. doi: 10.1016/bs.pmbts.2018.08.001. Epub 2018 Oct 15. Prog Mol Biol Transl Sci. 2018. PMID: 30470293 Review.

9

Analysis of functional responses at G protein-coupled receptors: estimation of relative affinity constants for the inactive receptor state.

Ehlert FJ, Griffin MT, Suga H. Ehlert FJ, et al. J Pharmacol Exp Ther. 2011 Aug;338(2):658-70. doi: 10.1124/jpet.111.179291. Epub 2011 May 16. J Pharmacol Exp Ther. 2011. PMID: 21576380 Free PMC article.

10

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP, Sexton PM, Kenakin TP, Ehlert FJ, Spedding M, Langmead CJ. Christopoulos A, et al. Among authors: ehlert fj. Pharmacol Rev. 2014 Oct;66(4):918-47. doi: 10.1124/pr.114.008862. Pharmacol Rev. 2014. PMID: 25026896 Free PMC article.

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