Silvestri R - Search Results

1

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R. La Regina G, et al. Among authors: silvestri r. J Med Chem. 2015 Aug 13;58(15):5789-807. doi: 10.1021/acs.jmedchem.5b00310. Epub 2015 Jul 20. J Med Chem. 2015. PMID: 26132075 Free PMC article.

2

2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.

Artico M, Silvestri R, Massa S, Loi AG, Corrias S, Piras G, La Colla P. Artico M, et al. Among authors: silvestri r. J Med Chem. 1996 Jan 19;39(2):522-30. doi: 10.1021/jm950568w. J Med Chem. 1996. PMID: 8558522

3

Synthesis and biological evaluation of 5H-indolo [3,2-b][1,5]benzothiazepine derivatives, designed as conformationally constrained analogues of the human immunodeficiency virus type 1 reverse transcriptase inhibitor L-737,126.

Silvestri R, Artico M, Bruno B, Massa S, Novellino E, Greco G, Marongiu ME, Pani A, De Montis A, La Colla P. Silvestri R, et al. Antivir Chem Chemother. 1998 Mar;9(2):139-48. doi: 10.1177/095632029800900205. Antivir Chem Chemother. 1998. PMID: 9875385

4

Structure-based design, synthesis, and biological evaluation of novel pyrrolyl aryl sulfones: HIV-1 non-nucleoside reverse transcriptase inhibitors active at nanomolar concentrations.

Artico M, Silvestri R, Pagnozzi E, Bruno B, Novellino E, Greco G, Massa S, Ettorre A, Loi AG, Scintu F, La Colla P. Artico M, et al. Among authors: silvestri r. J Med Chem. 2000 May 4;43(9):1886-91. doi: 10.1021/jm9901125. J Med Chem. 2000. PMID: 10794705

5

Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors.

Silvestri R, Artico M, De Martino G, Novellino E, Greco G, Lavecchia A, Massa S, Loi AG, Doratiotto S, La Colla P. Silvestri R, et al. Bioorg Med Chem. 2000 Sep;8(9):2305-9. doi: 10.1016/s0968-0896(00)00144-9. Bioorg Med Chem. 2000. PMID: 11026542

6

Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase.

Silvestri R, Artico M, De Martino G, Ragno R, Massa S, Loddo R, Murgioni C, Loi AG, La Colla P, Pani A. Silvestri R, et al. J Med Chem. 2002 Apr 11;45(8):1567-76. doi: 10.1021/jm010904a. J Med Chem. 2002. PMID: 11931611

7

Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B.

Silvestri R, La Regina G, De Martino G, Artico M, Befani O, Palumbo M, Agostinelli E, Turini P. Silvestri R, et al. J Med Chem. 2003 Mar 13;46(6):917-20. doi: 10.1021/jm0256124. J Med Chem. 2003. PMID: 12620068

8

Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.

Silvestri R, De Martino G, La Regina G, Artico M, Massa S, Vargiu L, Mura M, Loi AG, Marceddu T, La Colla P. Silvestri R, et al. J Med Chem. 2003 Jun 5;46(12):2482-93. doi: 10.1021/jm0211063. J Med Chem. 2003. PMID: 12773052

9

Anti-HIV-1 activity of pyrryl aryl sulfone (PAS) derivatives: synthesis and SAR studies of novel esters and amides at the position 2 of the pyrrole nucleus.

Silvestri R, Artico M, La Regina G, De Martino G, La Colla M, Loddo R, La Colla P. Silvestri R, et al. Farmaco. 2004 Mar;59(3):201-10. doi: 10.1016/j.farmac.2003.11.004. Farmaco. 2004. PMID: 14987983

10

Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations.

Silvestri R, Artico M, De Martino G, La Regina G, Loddo R, La Colla M, Mura M, La Colla P. Silvestri R, et al. J Med Chem. 2004 Jul 15;47(15):3892-6. doi: 10.1021/jm031147e. J Med Chem. 2004. PMID: 15239667

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