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Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.
Bergen AW, Michel M, Nishita D, Krasnow R, Javitz HS, Conneely KN, Lessov-Schlaggar CN, Hops H, Zhu AZ, Baurley JW, McClure JB, Hall SM, Baker TB, Conti DV, Benowitz NL, Lerman C, Tyndale RF, Swan GE; Transdisciplinary Research in Cancer of the Lung Research Team. Bergen AW, et al. Among authors: tyndale rf. PLoS One. 2015 Jul 1;10(7):e0126113. doi: 10.1371/journal.pone.0126113. eCollection 2015. PLoS One. 2015. PMID: 26132489 Free PMC article.
Mimicking gene defects to treat drug dependence.
Sellers EM, Tyndale RF. Sellers EM, et al. Among authors: tyndale rf. Ann N Y Acad Sci. 2000;909:233-46. doi: 10.1111/j.1749-6632.2000.tb06685.x. Ann N Y Acad Sci. 2000. PMID: 10911933 Review.
Deficient C-oxidation of nicotine continued.
Benowitz NL, Griffin C, Tyndale R. Benowitz NL, et al. Clin Pharmacol Ther. 2001 Dec;70(6):567. doi: 10.1067/mcp.2001.120252. Clin Pharmacol Ther. 2001. PMID: 11753274 No abstract available.
A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.
Tyndale RF, Pianezza ML, Sellers EM. Tyndale RF, et al. Nicotine Tob Res. 1999;1 Suppl 2:S63-7; discussion S69-70. doi: 10.1080/14622299050011831. Nicotine Tob Res. 1999. PMID: 11768189 Review.
This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if dependent, how impairment of the CYP2A6 gene function decreases the number of cigarettes consumed by smokers (Pianezza M, Sellers EM, Tyndale
This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if depend …
CYP2A6 genetic variation and potential consequences.
Xu C, Goodz S, Sellers EM, Tyndale RF. Xu C, et al. Among authors: tyndale rf. Adv Drug Deliv Rev. 2002 Nov 18;54(10):1245-56. doi: 10.1016/s0169-409x(02)00065-0. Adv Drug Deliv Rev. 2002. PMID: 12406643 Review.
446 results