Cook SJ - Search Results

1

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome.

Najas S, Arranz J, Lochhead PA, Ashford AL, Oxley D, Delabar JM, Cook SJ, Barallobre MJ, Arbonés ML. Najas S, et al. Among authors: cook sj. EBioMedicine. 2015 Jan 17;2(2):120-34. doi: 10.1016/j.ebiom.2015.01.010. eCollection 2015. EBioMedicine. 2015. PMID: 26137553 Free PMC article.

2

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover.

Densham RM, Todd DE, Balmanno K, Cook SJ. Densham RM, et al. Among authors: cook sj. Cell Signal. 2008 Nov;20(11):1986-94. doi: 10.1016/j.cellsig.2008.07.005. Epub 2008 Jul 10. Cell Signal. 2008. PMID: 18664382

3

CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.

Gilley R, Lochhead PA, Balmanno K, Oxley D, Clark J, Cook SJ. Gilley R, et al. Among authors: cook sj. Cell Signal. 2012 Jan;24(1):170-80. doi: 10.1016/j.cellsig.2011.08.018. Epub 2011 Sep 8. Cell Signal. 2012. PMID: 21924351

4

ERK5 and its role in tumour development.

Lochhead PA, Gilley R, Cook SJ. Lochhead PA, et al. Among authors: cook sj. Biochem Soc Trans. 2012 Feb;40(1):251-6. doi: 10.1042/BST20110663. Biochem Soc Trans. 2012. PMID: 22260700 Review.

5

FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency.

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D, Paul YL, Walter J, Cook SJ, Andrews S, Branco MR, Reik W. Ficz G, et al. Among authors: cook sj. Cell Stem Cell. 2013 Sep 5;13(3):351-9. doi: 10.1016/j.stem.2013.06.004. Epub 2013 Jul 11. Cell Stem Cell. 2013. PMID: 23850245 Free PMC article.

6

A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).

Ashford AL, Oxley D, Kettle J, Hudson K, Guichard S, Cook SJ, Lochhead PA. Ashford AL, et al. Among authors: cook sj. Biochem J. 2014 Jan 1;457(1):43-56. doi: 10.1042/BJ20130461. Biochem J. 2014. PMID: 24134204

7

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

Ashford AL, Dunkley TP, Cockerill M, Rowlinson RA, Baak LM, Gallo R, Balmanno K, Goodwin LM, Ward RA, Lochhead PA, Guichard S, Hudson K, Cook SJ. Ashford AL, et al. Among authors: cook sj. Cell Mol Life Sci. 2016 Feb;73(4):883-900. doi: 10.1007/s00018-015-2032-x. Epub 2015 Sep 7. Cell Mol Life Sci. 2016. PMID: 26346493 Free PMC article.

8

Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.

Lochhead PA, Clark J, Wang LZ, Gilmour L, Squires M, Gilley R, Foxton C, Newell DR, Wedge SR, Cook SJ. Lochhead PA, et al. Among authors: cook sj. Cell Cycle. 2016;15(4):506-18. doi: 10.1080/15384101.2015.1120915. Cell Cycle. 2016. PMID: 26959608 Free PMC article.

9

MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF^V600E amplification whereas KRAS^G13D amplification promotes EMT-chemoresistance.

Sale MJ, Balmanno K, Saxena J, Ozono E, Wojdyla K, McIntyre RE, Gilley R, Woroniuk A, Howarth KD, Hughes G, Dry JR, Arends MJ, Caro P, Oxley D, Ashton S, Adams DJ, Saez-Rodriguez J, Smith PD, Cook SJ. Sale MJ, et al. Among authors: cook sj. Nat Commun. 2019 May 2;10(1):2030. doi: 10.1038/s41467-019-09438-w. Nat Commun. 2019. PMID: 31048689 Free PMC article.

10

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.

Odle RI, Walker SA, Oxley D, Kidger AM, Balmanno K, Gilley R, Okkenhaug H, Florey O, Ktistakis NT, Cook SJ. Odle RI, et al. Among authors: cook sj. Mol Cell. 2020 Jan 16;77(2):228-240.e7. doi: 10.1016/j.molcel.2019.10.016. Epub 2019 Nov 13. Mol Cell. 2020. PMID: 31733992 Free PMC article.

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