Oxley D - Search Results

1

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome.

Najas S, Arranz J, Lochhead PA, Ashford AL, Oxley D, Delabar JM, Cook SJ, Barallobre MJ, Arbonés ML. Najas S, et al. Among authors: oxley d. EBioMedicine. 2015 Jan 17;2(2):120-34. doi: 10.1016/j.ebiom.2015.01.010. eCollection 2015. EBioMedicine. 2015. PMID: 26137553 Free PMC article.

2

A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).

Ashford AL, Oxley D, Kettle J, Hudson K, Guichard S, Cook SJ, Lochhead PA. Ashford AL, et al. Among authors: oxley d. Biochem J. 2014 Jan 1;457(1):43-56. doi: 10.1042/BJ20130461. Biochem J. 2014. PMID: 24134204

3

CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.

Gilley R, Lochhead PA, Balmanno K, Oxley D, Clark J, Cook SJ. Gilley R, et al. Among authors: oxley d. Cell Signal. 2012 Jan;24(1):170-80. doi: 10.1016/j.cellsig.2011.08.018. Epub 2011 Sep 8. Cell Signal. 2012. PMID: 21924351

4

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors.

Lochhead PA, Tucker JA, Tatum NJ, Wang J, Oxley D, Kidger AM, Johnson VP, Cassidy MA, Gray NS, Noble MEM, Cook SJ. Lochhead PA, et al. Among authors: oxley d. Nat Commun. 2020 Mar 13;11(1):1383. doi: 10.1038/s41467-020-15031-3. Nat Commun. 2020. PMID: 32170057 Free PMC article.

5

FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency.

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D, Paul YL, Walter J, Cook SJ, Andrews S, Branco MR, Reik W. Ficz G, et al. Among authors: oxley d. Cell Stem Cell. 2013 Sep 5;13(3):351-9. doi: 10.1016/j.stem.2013.06.004. Epub 2013 Jul 11. Cell Stem Cell. 2013. PMID: 23850245 Free PMC article.

6

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis.

Odle RI, Walker SA, Oxley D, Kidger AM, Balmanno K, Gilley R, Okkenhaug H, Florey O, Ktistakis NT, Cook SJ. Odle RI, et al. Among authors: oxley d. Mol Cell. 2020 Jan 16;77(2):228-240.e7. doi: 10.1016/j.molcel.2019.10.016. Epub 2019 Nov 13. Mol Cell. 2020. PMID: 31733992 Free PMC article.

7

MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF^V600E amplification whereas KRAS^G13D amplification promotes EMT-chemoresistance.

Sale MJ, Balmanno K, Saxena J, Ozono E, Wojdyla K, McIntyre RE, Gilley R, Woroniuk A, Howarth KD, Hughes G, Dry JR, Arends MJ, Caro P, Oxley D, Ashton S, Adams DJ, Saez-Rodriguez J, Smith PD, Cook SJ. Sale MJ, et al. Among authors: oxley d. Nat Commun. 2019 May 2;10(1):2030. doi: 10.1038/s41467-019-09438-w. Nat Commun. 2019. PMID: 31048689 Free PMC article.

8

p38α MAPK regulates adult muscle stem cell fate by restricting progenitor proliferation during postnatal growth and repair.

Brien P, Pugazhendhi D, Woodhouse S, Oxley D, Pell JM. Brien P, et al. Among authors: oxley d. Stem Cells. 2013 Aug;31(8):1597-610. doi: 10.1002/stem.1399. Stem Cells. 2013. PMID: 23592450

9

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

Latos PA, Goncalves A, Oxley D, Mohammed H, Turro E, Hemberger M. Latos PA, et al. Among authors: oxley d. Nat Commun. 2015 Jul 24;6:7776. doi: 10.1038/ncomms8776. Nat Commun. 2015. PMID: 26206133 Free PMC article.

10

DNA methylation profiles define stem cell identity and reveal a tight embryonic-extraembryonic lineage boundary.

Senner CE, Krueger F, Oxley D, Andrews S, Hemberger M. Senner CE, et al. Among authors: oxley d. Stem Cells. 2012 Dec;30(12):2732-45. doi: 10.1002/stem.1249. Stem Cells. 2012. PMID: 23034951

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