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MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.
Groothuizen FS, Winkler I, Cristóvão M, Fish A, Winterwerp HH, Reumer A, Marx AD, Hermans N, Nicholls RA, Murshudov GN, Lebbink JH, Friedhoff P, Sixma TK. Groothuizen FS, et al. Among authors: winterwerp hh. Elife. 2015 Jul 11;4:e06744. doi: 10.7554/eLife.06744. Elife. 2015. PMID: 26163658 Free PMC article.
The selection process of licensing a DNA mismatch for repair.
Fernandez-Leiro R, Bhairosing-Kok D, Kunetsky V, Laffeber C, Winterwerp HH, Groothuizen F, Fish A, Lebbink JHG, Friedhoff P, Sixma TK, Lamers MH. Fernandez-Leiro R, et al. Among authors: winterwerp hh. Nat Struct Mol Biol. 2021 Apr;28(4):373-381. doi: 10.1038/s41594-021-00577-7. Epub 2021 Apr 5. Nat Struct Mol Biol. 2021. PMID: 33820992
Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair.
Hermans N, Laffeber C, Cristovão M, Artola-Borán M, Mardenborough Y, Ikpa P, Jaddoe A, Winterwerp HH, Wyman C, Jiricny J, Kanaar R, Friedhoff P, Lebbink JH. Hermans N, et al. Among authors: winterwerp hh. Nucleic Acids Res. 2016 Aug 19;44(14):6770-86. doi: 10.1093/nar/gkw411. Epub 2016 May 12. Nucleic Acids Res. 2016. PMID: 27174933 Free PMC article.
Sharp kinking of a coiled-coil in MutS allows DNA binding and release.
Bhairosing-Kok D, Groothuizen FS, Fish A, Dharadhar S, Winterwerp HHK, Sixma TK. Bhairosing-Kok D, et al. Among authors: winterwerp hhk. Nucleic Acids Res. 2019 Sep 19;47(16):8888-8898. doi: 10.1093/nar/gkz649. Nucleic Acids Res. 2019. PMID: 31372631 Free PMC article.
23 results