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Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.
Samadi A, Marco-Contelles J, Soriano E, Alvarez-Pérez M, Chioua M, Romero A, González-Lafuente L, Gandía L, Roda JM, López MG, Villarroya M, García AG, Ríos Cde L. Samadi A, et al. Bioorg Med Chem. 2010 Aug 15;18(16):5861-72. doi: 10.1016/j.bmc.2010.06.095. Epub 2010 Jul 3. Bioorg Med Chem. 2010. PMID: 20656495
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Samadi A, Valderas C, de los Ríos C, Bastida A, Chioua M, González-Lafuente L, Colmena I, Gandía L, Romero A, Del Barrio L, Martín-de-Saavedra MD, López MG, Villarroya M, Marco-Contelles J. Samadi A, et al. Bioorg Med Chem. 2011 Jan 1;19(1):122-33. doi: 10.1016/j.bmc.2010.11.040. Epub 2010 Nov 26. Bioorg Med Chem. 2011. PMID: 21163662
Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.
González-Lafuente L, Egea J, León R, Martínez-Sanz FJ, Monjas L, Perez C, Merino C, García-De Diego AM, Rodríguez-Franco MI, García AG, Villarroya M, López MG, de Los Ríos C. González-Lafuente L, et al. ACS Chem Neurosci. 2012 Jul 18;3(7):519-29. doi: 10.1021/cn300009e. Epub 2012 Mar 26. ACS Chem Neurosci. 2012. PMID: 22860221 Free PMC article.
PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.
Lorrio S, Romero A, González-Lafuente L, Lajarín-Cuesta R, Martínez-Sanz FJ, Estrada M, Samadi A, Marco-Contelles J, Rodríguez-Franco MI, Villarroya M, López MG, de los Ríos C. Lorrio S, et al. ACS Chem Neurosci. 2013 Sep 18;4(9):1267-77. doi: 10.1021/cn400050p. Epub 2013 Jun 13. ACS Chem Neurosci. 2013. PMID: 23763493 Free PMC article.
Heme-Oxygenase I and PCG-1α Regulate Mitochondrial Biogenesis via Microglial Activation of Alpha7 Nicotinic Acetylcholine Receptors Using PNU282987.
Navarro E, Gonzalez-Lafuente L, Pérez-Liébana I, Buendia I, López-Bernardo E, Sánchez-Ramos C, Prieto I, Cuadrado A, Satrustegui J, Cadenas S, Monsalve M, López MG. Navarro E, et al. Antioxid Redox Signal. 2017 Jul 10;27(2):93-105. doi: 10.1089/ars.2016.6698. Epub 2016 Sep 30. Antioxid Redox Signal. 2017. PMID: 27554853
ConBr, A Lectin Purified from the Seeds of Canavalia brasiliensis, Protects Against Ischemia in Organotypic Culture of Rat Hippocampus: Potential Implication of Voltage-Gated Calcium Channels.
Rieger DK, Navarro E, Buendia I, Parada E, González-Lafuente L, Leon R, Costa AP, Heinrich IA, Nascimento KS, Cavada BS, Lopez MG, Egea J, Leal RB. Rieger DK, et al. Neurochem Res. 2017 Feb;42(2):347-359. doi: 10.1007/s11064-016-2078-7. Epub 2016 Oct 17. Neurochem Res. 2017. PMID: 27747481
Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®).
Romero A, Parada E, González-Lafuente L, Farré-Alins V, Ramos E, Cacabelos R, Egea J. Romero A, et al. CNS Neurosci Ther. 2017 May;23(5):450-452. doi: 10.1111/cns.12693. Epub 2017 Mar 30. CNS Neurosci Ther. 2017. PMID: 28371323 Free PMC article. No abstract available.
35 results