Spiller KJ - Search Results

1

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43.

Walker AK, Spiller KJ, Ge G, Zheng A, Xu Y, Zhou M, Tripathy K, Kwong LK, Trojanowski JQ, Lee VM. Walker AK, et al. Among authors: spiller kj. Acta Neuropathol. 2015 Nov;130(5):643-60. doi: 10.1007/s00401-015-1460-x. Epub 2015 Jul 22. Acta Neuropathol. 2015. PMID: 26197969 Free PMC article.

2

Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy.

Spiller KJ, Cheung CJ, Restrepo CR, Kwong LK, Stieber AM, Trojanowski JQ, Lee VM. Spiller KJ, et al. J Neurosci. 2016 Jul 20;36(29):7707-17. doi: 10.1523/JNEUROSCI.1457-16.2016. J Neurosci. 2016. PMID: 27445147 Free PMC article.

3

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.

Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM. Spiller KJ, et al. Nat Neurosci. 2018 Mar;21(3):329-340. doi: 10.1038/s41593-018-0083-7. Epub 2018 Feb 20. Nat Neurosci. 2018. PMID: 29463850 Free PMC article.

4

Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice.

Spiller KJ, Restrepo CR, Khan T, Stieber AM, Kwong LK, Trojanowski JQ, Lee VM. Spiller KJ, et al. Acta Neuropathol Commun. 2016 Sep 29;4(1):105. doi: 10.1186/s40478-016-0377-5. Acta Neuropathol Commun. 2016. PMID: 27687289 Free PMC article.

5

Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice.

Spiller KJ, Khan T, Dominique MA, Restrepo CR, Cotton-Samuel D, Levitan M, Jafar-Nejad P, Zhang B, Soriano A, Rigo F, Trojanowski JQ, Lee VM. Spiller KJ, et al. Neurobiol Dis. 2019 Apr;124:133-140. doi: 10.1016/j.nbd.2018.11.013. Epub 2018 Nov 17. Neurobiol Dis. 2019. PMID: 30458231 Free PMC article.

6

Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery.

Hunter M, Spiller KJ, Dominique MA, Xu H, Hunter FW, Fang TC, Canter RG, Roberts CJ, Ransohoff RM, Trojanowski JQ, Lee VM. Hunter M, et al. Among authors: spiller kj. Acta Neuropathol Commun. 2021 Aug 19;9(1):140. doi: 10.1186/s40478-021-01239-x. Acta Neuropathol Commun. 2021. PMID: 34412701 Free PMC article.

7

Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis.

Hur SK, Hunter M, Dominique MA, Farag M, Cotton-Samuel D, Khan T, Trojanowski JQ, Spiller KJ, Lee VM. Hur SK, et al. Among authors: spiller kj. Acta Neuropathol Commun. 2022 May 14;10(1):75. doi: 10.1186/s40478-022-01373-0. Acta Neuropathol Commun. 2022. PMID: 35568882 Free PMC article.

8

Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration.

Kaplan A, Spiller KJ, Towne C, Kanning KC, Choe GT, Geber A, Akay T, Aebischer P, Henderson CE. Kaplan A, et al. Among authors: spiller kj. Neuron. 2014 Jan 22;81(2):333-48. doi: 10.1016/j.neuron.2013.12.009. Neuron. 2014. PMID: 24462097 Free PMC article.

9

A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress.

Thams S, Lowry ER, Larraufie MH, Spiller KJ, Li H, Williams DJ, Hoang P, Jiang E, Williams LA, Sandoe J, Eggan K, Lieberam I, Kanning KC, Stockwell BR, Henderson CE, Wichterle H. Thams S, et al. Among authors: spiller kj. Mol Ther. 2019 Jan 2;27(1):87-101. doi: 10.1016/j.ymthe.2018.10.010. Epub 2018 Oct 19. Mol Ther. 2019. PMID: 30446391 Free PMC article.

10

UPLC-MS/MS assay for the simultaneous determination of catecholamines and their metabolites at low pg/mg in rat/mouse striatum.

Lin Y, Spiller K, Aras R, Jian W. Lin Y, et al. J Pharm Biomed Anal. 2022 May 10;213:114697. doi: 10.1016/j.jpba.2022.114697. Epub 2022 Mar 1. J Pharm Biomed Anal. 2022. PMID: 35272126

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