Mannens G - Search Results

1

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

T'jollyn H, Snoeys J, Vermeulen A, Michelet R, Cuyckens F, Mannens G, Van Peer A, Annaert P, Allegaert K, Van Bocxlaer J, Boussery K. T'jollyn H, et al. Among authors: mannens g. AAPS J. 2015 Nov;17(6):1376-87. doi: 10.1208/s12248-015-9803-z. Epub 2015 Jul 25. AAPS J. 2015. PMID: 26209290 Free PMC article.

2

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

T'jollyn H, Snoeys J, Colin P, Van Bocxlaer J, Annaert P, Cuyckens F, Vermeulen A, Van Peer A, Allegaert K, Mannens G, Boussery K. T'jollyn H, et al. Among authors: mannens g. Pharm Res. 2015 Jan;32(1):260-74. doi: 10.1007/s11095-014-1460-x. Epub 2014 Jul 22. Pharm Res. 2015. PMID: 25048637

3

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

T'jollyn H, Snoeys J, Van Bocxlaer J, De Bock L, Annaert P, Van Peer A, Allegaert K, Mannens G, Vermeulen A, Boussery K. T'jollyn H, et al. Among authors: mannens g. Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):537-543. doi: 10.1007/s13318-016-0355-0. Eur J Drug Metab Pharmacokinet. 2017. PMID: 27317395

4

Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes.

de Vries R, Jacobs F, Mannens G, Snoeys J, Cuyckens F, Chien C, Ward P. de Vries R, et al. Among authors: mannens g. Drug Metab Dispos. 2019 May;47(5):453-464. doi: 10.1124/dmd.118.084517. Epub 2019 Feb 20. Drug Metab Dispos. 2019. PMID: 30787101 Clinical Trial.

5

Prediction of Drug-Drug Interactions After Esketamine Intranasal Administration Using a Physiologically Based Pharmacokinetic Model.

Willemin ME, Zannikos P, Mannens G, de Zwart L, Snoeys J. Willemin ME, et al. Among authors: mannens g. Clin Pharmacokinet. 2022 Aug;61(8):1115-1128. doi: 10.1007/s40262-022-01123-4. Epub 2022 May 17. Clin Pharmacokinet. 2022. PMID: 35579824

6

Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use.

T'jollyn H, Boussery K, Mortishire-Smith RJ, Coe K, De Boeck B, Van Bocxlaer JF, Mannens G. T'jollyn H, et al. Among authors: mannens g. Drug Metab Dispos. 2011 Nov;39(11):2066-75. doi: 10.1124/dmd.111.039982. Epub 2011 Aug 10. Drug Metab Dispos. 2011. PMID: 21832003

7

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

Vermeir M, Annaert P, Mamidi RN, Roymans D, Meuldermans W, Mannens G. Vermeir M, et al. Among authors: mannens g. Expert Opin Drug Metab Toxicol. 2005 Jun;1(1):75-90. doi: 10.1517/17425255.1.1.75. Expert Opin Drug Metab Toxicol. 2005. PMID: 16922654 Review.

8

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

Leclercq L, Cuyckens F, Mannens GS, de Vries R, Timmerman P, Evans DC. Leclercq L, et al. Chem Res Toxicol. 2009 Feb;22(2):280-93. doi: 10.1021/tx800432c. Chem Res Toxicol. 2009. PMID: 19183054 Review.

9

Absorption, metabolism, and excretion of oral ¹⁴C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men.

Scheers E, Leclercq L, de Jong J, Bode N, Bockx M, Laenen A, Cuyckens F, Skee D, Murphy J, Sukbuntherng J, Mannens G. Scheers E, et al. Among authors: mannens g. Drug Metab Dispos. 2015 Feb;43(2):289-97. doi: 10.1124/dmd.114.060061. Epub 2014 Dec 8. Drug Metab Dispos. 2015. PMID: 25488930 Clinical Trial.

10

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Vermeir M, Hemeryck A, Cuyckens F, Francesch A, Bockx M, Van Houdt J, Steemans K, Mannens G, Avilés P, De Coster R. Vermeir M, et al. Among authors: mannens g. Biochem Pharmacol. 2009 May 15;77(10):1642-54. doi: 10.1016/j.bcp.2009.02.020. Epub 2009 Mar 10. Biochem Pharmacol. 2009. PMID: 19426702

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