Hochhauser D - Search Results

1

The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1).

Vena F, Li Causi E, Rodriguez-Justo M, Goodstal S, Hagemann T, Hartley JA, Hochhauser D. Vena F, et al. Among authors: hochhauser d. Clin Cancer Res. 2015 Dec 15;21(24):5563-77. doi: 10.1158/1078-0432.CCR-15-0485. Epub 2015 Jul 30. Clin Cancer Res. 2015. PMID: 26228206

2

Transcriptional regulation of topoisomerase II alpha at confluence and pharmacological modulation of expression by bis-benzimidazole drugs.

Tolner B, Hartley JA, Hochhauser D. Tolner B, et al. Among authors: hochhauser d. Mol Pharmacol. 2001 Apr;59(4):699-706. doi: 10.1124/mol.59.4.699. Mol Pharmacol. 2001. PMID: 11259613

3

Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material.

Webley SD, Francis RJ, Pedley RB, Sharma SK, Begent RH, Hartley JA, Hochhauser D. Webley SD, et al. Among authors: hochhauser d. Br J Cancer. 2001 Jun 15;84(12):1671-6. doi: 10.1054/bjoc.2001.1843. Br J Cancer. 2001. PMID: 11401322 Free PMC article.

4

Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma.

Spanswick VJ, Craddock C, Sekhar M, Mahendra P, Shankaranarayana P, Hughes RG, Hochhauser D, Hartley JA. Spanswick VJ, et al. Among authors: hochhauser d. Blood. 2002 Jul 1;100(1):224-9. doi: 10.1182/blood.v100.1.224. Blood. 2002. PMID: 12070031 Free article.

5

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

Hartley JA, Spanswick VJ, Brooks N, Clingen PH, McHugh PJ, Hochhauser D, Pedley RB, Kelland LR, Alley MC, Schultz R, Hollingshead MG, Schweikart KM, Tomaszewski JE, Sausville EA, Gregson SJ, Howard PW, Thurston DE. Hartley JA, et al. Among authors: hochhauser d. Cancer Res. 2004 Sep 15;64(18):6693-9. doi: 10.1158/0008-5472.CAN-03-2941. Cancer Res. 2004. PMID: 15374986

6

Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839).

Friedmann B, Caplin M, Hartley JA, Hochhauser D. Friedmann B, et al. Among authors: hochhauser d. Clin Cancer Res. 2004 Oct 1;10(19):6476-86. doi: 10.1158/1078-0432.CCR-04-0586. Clin Cancer Res. 2004. PMID: 15475435

7

Assessment of the significance of mitochondrial DNA damage by chemotherapeutic agents.

Lo S, Tolner B, Taanman JW, Cooper JM, Gu M, Hartley JA, Schapira AH, Hochhauser D. Lo S, et al. Among authors: hochhauser d. Int J Oncol. 2005 Aug;27(2):337-44. Int J Oncol. 2005. PMID: 16010413

8

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.

Friedmann BJ, Caplin M, Savic B, Shah T, Lord CJ, Ashworth A, Hartley JA, Hochhauser D. Friedmann BJ, et al. Among authors: hochhauser d. Mol Cancer Ther. 2006 Feb;5(2):209-18. doi: 10.1158/1535-7163.MCT-05-0239. Mol Cancer Ther. 2006. PMID: 16505093 Free article.

9

Modulation of topoisomerase IIalpha expression by a DNA sequence-specific polyamide.

Hochhauser D, Kotecha M, O'hare C, Morris PJ, Hartley JM, Taherbhai Z, Harris D, Forni C, Mantovani R, Lee M, Hartley JA. Hochhauser D, et al. Mol Cancer Ther. 2007 Jan;6(1):346-54. doi: 10.1158/1535-7163.MCT-06-0503. Mol Cancer Ther. 2007. PMID: 17237293

10

Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78.

Kotecha M, Kluza J, Wells G, O'Hare CC, Forni C, Mantovani R, Howard PW, Morris P, Thurston DE, Hartley JA, Hochhauser D. Kotecha M, et al. Among authors: hochhauser d. Mol Cancer Ther. 2008 May;7(5):1319-28. doi: 10.1158/1535-7163.MCT-07-0475. Mol Cancer Ther. 2008. PMID: 18483319

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