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Page 1
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
Farmer LJ, Ledeboer MW, Hoock T, Arnost MJ, Bethiel RS, Bennani YL, Black JJ, Brummel CL, Chakilam A, Dorsch WA, Fan B, Cochran JE, Halas S, Harrington EM, Hogan JK, Howe D, Huang H, Jacobs DH, Laitinen LM, Liao S, Mahajan S, Marone V, Martinez-Botella G, McCarthy P, Messersmith D, Namchuk M, Oh L, Penney MS, Pierce AC, Raybuck SA, Rugg A, Salituro FG, Saxena K, Shannon D, Shlyakter D, Swenson L, Tian SK, Town C, Wang J, Wang T, Wannamaker MW, Winquist RJ, Zuccola HJ. Farmer LJ, et al. Among authors: brummel cl. J Med Chem. 2015 Sep 24;58(18):7195-216. doi: 10.1021/acs.jmedchem.5b00301. Epub 2015 Sep 10. J Med Chem. 2015. PMID: 26230873
In vitro and in vivo isotope effects with hepatitis C protease inhibitors: enhanced plasma exposure of deuterated telaprevir versus telaprevir in rats.
Maltais F, Jung YC, Chen M, Tanoury J, Perni RB, Mani N, Laitinen L, Huang H, Liao S, Gao H, Tsao H, Block E, Ma C, Shawgo RS, Town C, Brummel CL, Howe D, Pazhanisamy S, Raybuck S, Namchuk M, Bennani YL. Maltais F, et al. Among authors: brummel cl. J Med Chem. 2009 Dec 24;52(24):7993-8001. doi: 10.1021/jm901023f. J Med Chem. 2009. PMID: 19894743
Evaluating LC-MS/MS To Measure Accumulation of Compounds within Bacteria.
Iyer R, Ye Z, Ferrari A, Duncan L, Tanudra MA, Tsao H, Wang T, Gao H, Brummel CL, Erwin AL. Iyer R, et al. Among authors: brummel cl. ACS Infect Dis. 2018 Sep 14;4(9):1336-1345. doi: 10.1021/acsinfecdis.8b00083. Epub 2018 Jul 13. ACS Infect Dis. 2018. PMID: 29961312
Bioanalytical solutions to acetonitrile shortages.
Gao H, Williams J, Carrier S, Brummel CL. Gao H, et al. Among authors: brummel cl. Bioanalysis. 2010 Sep;2(9):1627-40. doi: 10.4155/bio.10.76. Bioanalysis. 2010. PMID: 21083291 Review.
Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development.
Harbeson SL, Morgan AJ, Liu JF, Aslanian AM, Nguyen S, Bridson GW, Brummel CL, Wu L, Tung RD, Pilja L, Braman V, Uttamsingh V. Harbeson SL, et al. Among authors: brummel cl. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367. doi: 10.1124/jpet.117.241497. Epub 2017 Jun 13. J Pharmacol Exp Ther. 2017. PMID: 28611092 Clinical Trial.
15 results