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Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01.
Parham LR, Briley LP, Li L, Shen J, Newcombe PJ, King KS, Slater AJ, Dilthey A, Iqbal Z, McVean G, Cox CJ, Nelson MR, Spraggs CF. Parham LR, et al. Among authors: briley lp. Pharmacogenomics J. 2016 Apr;16(2):180-5. doi: 10.1038/tpj.2015.40. Epub 2015 May 19. Pharmacogenomics J. 2016. PMID: 25987243 Free PMC article. Clinical Trial.
Characterisation of the HLA-DRB1*07:01 biomarker for lapatinib-induced liver toxicity during treatment of early-stage breast cancer patients with lapatinib in combination with trastuzumab and/or taxanes.
Spraggs CF, Parham LR, Briley LP, Warren L, Williams LS, Fraser DJ, Jiang Z, Aziz Z, Ahmed S, Demetriou G, Mehta A, Jackson N, Byrne J, Andersson M, Toi M, Harris L, Gralow J, Zujewski JA, Crescenzo R, Armour A, Perez E, Piccart M. Spraggs CF, et al. Among authors: briley lp. Pharmacogenomics J. 2018 May 22;18(3):480-486. doi: 10.1038/tpj.2017.39. Epub 2017 Aug 8. Pharmacogenomics J. 2018. PMID: 28786423 Clinical Trial.
HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer.
Xu CF, Johnson T, Wang X, Carpenter C, Graves AP, Warren L, Xue Z, King KS, Fraser DJ, Stinnett S, Briley LP, Mitrica I, Spraggs CF, Nelson MR, Tada H, du Bois A, Powles T, Kaplowitz N, Pandite LN. Xu CF, et al. Among authors: briley lp. Clin Cancer Res. 2016 Mar 15;22(6):1371-7. doi: 10.1158/1078-0432.CCR-15-2044. Epub 2015 Nov 6. Clin Cancer Res. 2016. PMID: 26546620 Free PMC article.
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research.
Nelson MR, Bryc K, King KS, Indap A, Boyko AR, Novembre J, Briley LP, Maruyama Y, Waterworth DM, Waeber G, Vollenweider P, Oksenberg JR, Hauser SL, Stirnadel HA, Kooner JS, Chambers JC, Jones B, Mooser V, Bustamante CD, Roses AD, Burns DK, Ehm MG, Lai EH. Nelson MR, et al. Among authors: briley lp. Am J Hum Genet. 2008 Sep;83(3):347-58. doi: 10.1016/j.ajhg.2008.08.005. Epub 2008 Aug 28. Am J Hum Genet. 2008. PMID: 18760391 Free PMC article.
Effect of lapatinib on oral digoxin absorption in patients.
Koch KM, Smith DA, Botbyl J, Arya N, Briley LP, Cartee L, White JH, Beyer J, Dar MM, Chung HC, Chu Q, Bang YJ. Koch KM, et al. Among authors: briley lp. Clin Pharmacol Drug Dev. 2015 Nov;4(6):449-53. doi: 10.1002/cpdd.189. Epub 2015 Jun 2. Clin Pharmacol Drug Dev. 2015. PMID: 27137717 Clinical Trial.
Case-control single-marker and haplotypic association analysis of pedigree data.
Browning SR, Briley JD, Briley LP, Chandra G, Charnecki JH, Ehm MG, Johansson KA, Jones BJ, Karter AJ, Yarnall DP, Wagner MJ. Browning SR, et al. Among authors: briley lp, briley jd. Genet Epidemiol. 2005 Feb;28(2):110-22. doi: 10.1002/gepi.20051. Genet Epidemiol. 2005. PMID: 15578751
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