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OKN-007 decreases VEGFR-2 levels in a preclinical GL261 mouse glioma model.
de Souza PC, Smith N, Pody R, He T, Njoku C, Silasi-Mansat R, Lupu F, Meek B, Chen H, Dong Y, Saunders D, Orock A, Hodges E, Colijn S, Mamedova N, Towner RA. de Souza PC, et al. Among authors: njoku c. Am J Nucl Med Mol Imaging. 2015 Jun 15;5(4):363-78. eCollection 2015. Am J Nucl Med Mol Imaging. 2015. PMID: 26269774 Free PMC article.
OKN-007 decreases free radical levels in a preclinical F98 rat glioma model.
Coutinho de Souza P, Smith N, Atolagbe O, Ziegler J, Njoku C, Lerner M, Ehrenshaft M, Mason RP, Meek B, Plafker SM, Saunders D, Mamedova N, Towner RA. Coutinho de Souza P, et al. Among authors: njoku c. Free Radic Biol Med. 2015 Oct;87:157-68. doi: 10.1016/j.freeradbiomed.2015.06.026. Epub 2015 Jun 26. Free Radic Biol Med. 2015. PMID: 26119786 Free PMC article.
OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model.
de Souza PC, Balasubramanian K, Njoku C, Smith N, Gillespie DL, Schwager A, Abdullah O, Ritchey JW, Fung KM, Saunders D, Jensen RL, Towner RA. de Souza PC, et al. Among authors: njoku c. J Magn Reson Imaging. 2015 Dec;42(6):1582-91. doi: 10.1002/jmri.24935. Epub 2015 Apr 29. J Magn Reson Imaging. 2015. PMID: 25920494 Free PMC article.
Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007.
Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS 3rd, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL. Towner RA, et al. Among authors: njoku ce. Neuro Oncol. 2013 Mar;15(3):330-40. doi: 10.1093/neuonc/nos337. Epub 2013 Jan 17. Neuro Oncol. 2013. PMID: 23328810 Free PMC article.
ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.
Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. Ziegler J, et al. Among authors: njoku c. Neuro Oncol. 2017 Feb 1;19(2):175-185. doi: 10.1093/neuonc/now147. Neuro Oncol. 2017. PMID: 27416955 Free PMC article.
Motif mimetic of epsin perturbs tumor growth and metastasis.
Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Dong Y, et al. Among authors: njoku c. J Clin Invest. 2015 Dec;125(12):4349-64. doi: 10.1172/JCI80349. Epub 2015 Nov 16. J Clin Invest. 2015. PMID: 26571402 Free PMC article.
Motif mimetic of epsin perturbs tumor growth and metastasis.
Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Dong Y, et al. Among authors: njoku c. J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87344. Epub 2016 Mar 21. J Clin Invest. 2016. PMID: 26999611 Free PMC article. No abstract available.
135 results