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EMT-induced metabolite signature identifies poor clinical outcome.
Bhowmik SK, Ramirez-Peña E, Arnold JM, Putluri V, Sphyris N, Michailidis G, Putluri N, Ambs S, Sreekumar A, Mani SA. Bhowmik SK, et al. Among authors: sphyris n. Oncotarget. 2015 Dec 15;6(40):42651-60. doi: 10.18632/oncotarget.4765. Oncotarget. 2015. PMID: 26315396 Free PMC article.
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth.
Werden SJ, Sphyris N, Sarkar TR, Paranjape AN, LaBaff AM, Taube JH, Hollier BG, Ramirez-Peña EQ, Soundararajan R, den Hollander P, Powell E, Echeverria GV, Miura N, Chang JT, Piwnica-Worms H, Rosen JM, Mani SA. Werden SJ, et al. Among authors: sphyris n. Oncogene. 2016 Nov 17;35(46):5977-5988. doi: 10.1038/onc.2016.203. Epub 2016 Jun 13. Oncogene. 2016. PMID: 27292262 Free PMC article.
The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition.
Taube JH, Sphyris N, Johnson KS, Reisenauer KN, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Song JJ, Chang JT, Lee MG, Soundararajan R, Mani SA. Taube JH, et al. Among authors: sphyris n. Oncotarget. 2017 Jul 10;8(39):65548-65565. doi: 10.18632/oncotarget.19214. eCollection 2017 Sep 12. Oncotarget. 2017. PMID: 29029452 Free PMC article.
GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer.
Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Pietila M, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, Miura N, Davies P, Chang JT, Soundararajan R, Rosen JM, Mani SA. Vijay GV, et al. Among authors: sphyris n. Breast Cancer Res. 2019 Mar 7;21(1):37. doi: 10.1186/s13058-019-1125-0. Breast Cancer Res. 2019. PMID: 30845991 Free PMC article.
pIgR: frenemy of inflammation, EMT, and HCC progression.
Sphyris N, Mani SA. Sphyris N, et al. J Natl Cancer Inst. 2011 Nov 16;103(22):1644-5. doi: 10.1093/jnci/djr421. Epub 2011 Oct 24. J Natl Cancer Inst. 2011. PMID: 22025623 Free PMC article. No abstract available.
26 results