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The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.
Thottakara T, Friedrich FW, Reischmann S, Braumann S, Schlossarek S, Krämer E, Juhr D, Schlüter H, van der Velden J, Münch J, Patten M, Eschenhagen T, Moog-Lutz C, Carrier L. Thottakara T, et al. Among authors: patten m. J Mol Cell Cardiol. 2015 Oct;87:214-24. doi: 10.1016/j.yjmcc.2015.08.020. Epub 2015 Sep 3. J Mol Cell Cardiol. 2015. PMID: 26343497
FHL2 expression and variants in hypertrophic cardiomyopathy.
Friedrich FW, Reischmann S, Schwalm A, Unger A, Ramanujam D, Münch J, Müller OJ, Hengstenberg C, Galve E, Charron P, Linke WA, Engelhardt S, Patten M, Richard P, van der Velden J, Eschenhagen T, Isnard R, Carrier L. Friedrich FW, et al. Among authors: patten m. Basic Res Cardiol. 2014;109(6):451. doi: 10.1007/s00395-014-0451-8. Epub 2014 Oct 31. Basic Res Cardiol. 2014. PMID: 25358972 Free PMC article.
Prediction of the estimated 5-year risk of sudden cardiac death and syncope or non-sustained ventricular tachycardia in patients with hypertrophic cardiomyopathy using late gadolinium enhancement and extracellular volume CMR.
Avanesov M, Münch J, Weinrich J, Well L, Säring D, Stehning C, Tahir E, Bohnen S, Radunski UK, Muellerleile K, Adam G, Patten M, Lund G. Avanesov M, et al. Among authors: patten m. Eur Radiol. 2017 Dec;27(12):5136-5145. doi: 10.1007/s00330-017-4869-x. Epub 2017 Jun 14. Eur Radiol. 2017. PMID: 28616729
Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes.
Prondzynski M, Krämer E, Laufer SD, Shibamiya A, Pless O, Flenner F, Müller OJ, Münch J, Redwood C, Hansen A, Patten M, Eschenhagen T, Mearini G, Carrier L. Prondzynski M, et al. Among authors: patten m. Mol Ther Nucleic Acids. 2017 Jun 16;7:475-486. doi: 10.1016/j.omtn.2017.05.008. Epub 2017 May 17. Mol Ther Nucleic Acids. 2017. PMID: 28624223 Free PMC article.
167 results