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An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1.
Chen L, Roake CM, Freund A, Batista PJ, Tian S, Yin YA, Gajera CR, Lin S, Lee B, Pech MF, Venteicher AS, Das R, Chang HY, Artandi SE. Chen L, et al. Among authors: roake cm. Cell. 2018 Jun 28;174(1):218-230.e13. doi: 10.1016/j.cell.2018.04.039. Epub 2018 May 24. Cell. 2018. PMID: 29804836 Free PMC article.
Regulation of human telomerase in homeostasis and disease.
Roake CM, Artandi SE. Roake CM, et al. Nat Rev Mol Cell Biol. 2020 Jul;21(7):384-397. doi: 10.1038/s41580-020-0234-z. Epub 2020 Apr 2. Nat Rev Mol Cell Biol. 2020. PMID: 32242127 Free PMC article. Review.
The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening.
Galati A, Scatolini L, Micheli E, Bavasso F, Cicconi A, Maccallini P, Chen L, Roake CM, Schoeftner S, Artandi SE, Gatti M, Cacchione S, Raffa GD. Galati A, et al. Among authors: roake cm. FEBS Lett. 2022 Jan;596(1):42-52. doi: 10.1002/1873-3468.14240. Epub 2021 Dec 5. FEBS Lett. 2022. PMID: 34817067 Free article.
HiChIRP reveals RNA-associated chromosome conformation.
Mumbach MR, Granja JM, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH, Guo JK, Gennert DG, Corces MR, Khavari PA, Atianand MK, Artandi SE, Fitzgerald KA, Greenleaf WJ, Chang HY. Mumbach MR, et al. Among authors: roake cm. Nat Methods. 2019 Jun;16(6):489-492. doi: 10.1038/s41592-019-0407-x. Epub 2019 May 27. Nat Methods. 2019. PMID: 31133759 Free PMC article.
15 results