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Cargo Delivery into the Brain by in vivo identified Transport Peptides.
Urich E, Schmucki R, Ruderisch N, Kitas E, Certa U, Jacobsen H, Schweitzer C, Bergadano A, Ebeling M, Loetscher H, Freskgård PO. Urich E, et al. Among authors: loetscher h. Sci Rep. 2015 Sep 28;5:14104. doi: 10.1038/srep14104. Sci Rep. 2015. PMID: 26411801 Free PMC article.
Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.
Ruderisch N, Schlatter D, Kuglstatter A, Guba W, Huber S, Cusulin C, Benz J, Rufer AC, Hoernschemeyer J, Schweitzer C, Bülau T, Gärtner A, Hoffmann E, Niewoehner J, Patsch C, Baumann K, Loetscher H, Kitas E, Freskgård PO. Ruderisch N, et al. Among authors: loetscher h. EBioMedicine. 2017 Oct;24:76-92. doi: 10.1016/j.ebiom.2017.09.004. Epub 2017 Sep 7. EBioMedicine. 2017. PMID: 28923680 Free PMC article.
Region-specific permeability of the blood-brain barrier upon pericyte loss.
Villaseñor R, Kuennecke B, Ozmen L, Ammann M, Kugler C, Grüninger F, Loetscher H, Freskgård PO, Collin L. Villaseñor R, et al. Among authors: loetscher h. J Cereb Blood Flow Metab. 2017 Dec;37(12):3683-3694. doi: 10.1177/0271678X17697340. Epub 2017 Mar 1. J Cereb Blood Flow Metab. 2017. PMID: 28273726 Free PMC article.
PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.
Richards JG, Higgins GA, Ouagazzal AM, Ozmen L, Kew JN, Bohrmann B, Malherbe P, Brockhaus M, Loetscher H, Czech C, Huber G, Bluethmann H, Jacobsen H, Kemp JA. Richards JG, et al. Among authors: loetscher h. J Neurosci. 2003 Oct 1;23(26):8989-9003. doi: 10.1523/JNEUROSCI.23-26-08989.2003. J Neurosci. 2003. PMID: 14523101 Free PMC article.
Presenilins are processed by caspase-type proteases.
Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grünberg J, Haass C, Jacobsen H. Loetscher H, et al. J Biol Chem. 1997 Aug 15;272(33):20655-9. doi: 10.1074/jbc.272.33.20655. J Biol Chem. 1997. PMID: 9252383 Free article.
63 results