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Time-Resolved Inspection of Ionizable Lipid-Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Early Endosomal Membrane Mimic.
Aliakbarinodehi N, Niederkofler S, Emilsson G, Parkkila P, Olsén E, Jing Y, Sjöberg M, Agnarsson B, Lindfors L, Höök F. Aliakbarinodehi N, et al. Among authors: lindfors l. ACS Nano. 2024 Aug 27;18(34):22989-23000. doi: 10.1021/acsnano.4c04519. Epub 2024 Aug 12. ACS Nano. 2024. PMID: 39133894 Free PMC article.
Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles.
Tesei G, Hsiao YW, Dabkowska A, Grönberg G, Yanez Arteta M, Ulkoski D, Bray DJ, Trulsson M, Ulander J, Lund M, Lindfors L. Tesei G, et al. Among authors: lindfors l. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2311700120. doi: 10.1073/pnas.2311700120. Epub 2024 Jan 4. Proc Natl Acad Sci U S A. 2024. PMID: 38175863 Free PMC article.
pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function.
Philipp J, Dabkowska A, Reiser A, Frank K, Krzysztoń R, Brummer C, Nickel B, Blanchet CE, Sudarsan A, Ibrahim M, Johansson S, Skantze P, Skantze U, Östman S, Johansson M, Henderson N, Elvevold K, Smedsrød B, Schwierz N, Lindfors L, Rädler JO. Philipp J, et al. Among authors: lindfors l. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2310491120. doi: 10.1073/pnas.2310491120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055742 Free PMC article.
Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions.
Nawaz M, Heydarkhan-Hagvall S, Tangruksa B, González-King Garibotti H, Jing Y, Maugeri M, Kohl F, Hultin L, Reyahi A, Camponeschi A, Kull B, Christoffersson J, Grimsholm O, Jennbacken K, Sundqvist M, Wiseman J, Bidar AW, Lindfors L, Synnergren J, Valadi H. Nawaz M, et al. Among authors: lindfors l. Adv Sci (Weinh). 2023 Apr;10(12):e2206187. doi: 10.1002/advs.202206187. Epub 2023 Feb 19. Adv Sci (Weinh). 2023. PMID: 36806740 Free PMC article.
52 results