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T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.
Beringer DX, Kleijwegt FS, Wiede F, van der Slik AR, Loh KL, Petersen J, Dudek NL, Duinkerken G, Laban S, Joosten A, Vivian JP, Chen Z, Uldrich AP, Godfrey DI, McCluskey J, Price DA, Radford KJ, Purcell AW, Nikolic T, Reid HH, Tiganis T, Roep BO, Rossjohn J. Beringer DX, et al. Among authors: chen z. Nat Immunol. 2015 Nov;16(11):1153-61. doi: 10.1038/ni.3271. Epub 2015 Oct 5. Nat Immunol. 2015. PMID: 26437244
Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity.
Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z, Kjer-Nielsen L, Mifsud NA, Tait BD, Holdsworth R, Almeida CA, Nolan D, Macdonald WA, Archbold JK, Kellerher AD, Marriott D, Mallal S, Bharadwaj M, Rossjohn J, McCluskey J. Chessman D, et al. Among authors: chen z. Immunity. 2008 Jun;28(6):822-32. doi: 10.1016/j.immuni.2008.04.020. Immunity. 2008. PMID: 18549801 Free article.
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J. Beddoe T, et al. Among authors: chen z. Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21. Immunity. 2009. PMID: 19464197 Free article.
T cell allorecognition via molecular mimicry.
Macdonald WA, Chen Z, Gras S, Archbold JK, Tynan FE, Clements CS, Bharadwaj M, Kjer-Nielsen L, Saunders PM, Wilce MC, Crawford F, Stadinsky B, Jackson D, Brooks AG, Purcell AW, Kappler JW, Burrows SR, Rossjohn J, McCluskey J. Macdonald WA, et al. Among authors: chen z. Immunity. 2009 Dec 18;31(6):897-908. doi: 10.1016/j.immuni.2009.09.025. Immunity. 2009. PMID: 20064448 Free article.
Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.
Burrows SR, Chen Z, Archbold JK, Tynan FE, Beddoe T, Kjer-Nielsen L, Miles JJ, Khanna R, Moss DJ, Liu YC, Gras S, Kostenko L, Brennan RM, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J. Burrows SR, et al. Among authors: chen z. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10608-13. doi: 10.1073/pnas.1004926107. Epub 2010 May 18. Proc Natl Acad Sci U S A. 2010. PMID: 20483993 Free PMC article.
Allelic polymorphism in the T cell receptor and its impact on immune responses.
Gras S, Chen Z, Miles JJ, Liu YC, Bell MJ, Sullivan LC, Kjer-Nielsen L, Brennan RM, Burrows JM, Neller MA, Khanna R, Purcell AW, Brooks AG, McCluskey J, Rossjohn J, Burrows SR. Gras S, et al. Among authors: chen z. J Exp Med. 2010 Jul 5;207(7):1555-67. doi: 10.1084/jem.20100603. Epub 2010 Jun 21. J Exp Med. 2010. PMID: 20566715 Free PMC article.
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