Holmes N - Search Results

1

A SNP in the Immunoregulatory Molecule CTLA-4 Controls mRNA Splicing In Vivo but Does Not Alter Diabetes Susceptibility in the NOD Mouse.

Jakubczik F, Jones K, Nichols J, Mansfield W, Cooke A, Holmes N. Jakubczik F, et al. Among authors: holmes n. Diabetes. 2016 Jan;65(1):120-8. doi: 10.2337/db15-1175. Epub 2015 Oct 8. Diabetes. 2016. PMID: 26450994 Free PMC article.

2

Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.

Holmes N, Cooke A. Holmes N, et al. Rev Diabet Stud. 2012 Winter;9(4):137-47. doi: 10.1900/RDS.2012.9.137. Epub 2012 Dec 28. Rev Diabet Stud. 2012. PMID: 23804257 Free PMC article. Review.

3

Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice.

Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, Notaridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M. Recino A, et al. Among authors: holmes n. Gene Ther. 2019 Feb;26(1-2):40-56. doi: 10.1038/s41434-018-0052-5. Epub 2018 Dec 4. Gene Ther. 2019. PMID: 30514969 Free PMC article.

4

Immunology. A splicing switch for T cells.

Holmes N. Holmes N. Science. 2008 Aug 1;321(5889):646-7. doi: 10.1126/science.1162294. Science. 2008. PMID: 18669848 No abstract available.

5

CD4+ T cell hyper-responsiveness in CD45 transgenic mice is independent of isoform.

Salmond RJ, McNeill L, Holmes N, Alexander DR. Salmond RJ, et al. Among authors: holmes n. Int Immunol. 2008 Jul;20(7):819-27. doi: 10.1093/intimm/dxn040. Epub 2008 Apr 30. Int Immunol. 2008. PMID: 18448457

6

CD45: all is not yet crystal clear.

Holmes N. Holmes N. Immunology. 2006 Feb;117(2):145-55. doi: 10.1111/j.1365-2567.2005.02265.x. Immunology. 2006. PMID: 16423050 Free PMC article. Review.

7

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

Byth KF, Conroy LA, Howlett S, Smith AJ, May J, Alexander DR, Holmes N. Byth KF, et al. Among authors: holmes n. J Exp Med. 1996 Apr 1;183(4):1707-18. doi: 10.1084/jem.183.4.1707. J Exp Med. 1996. PMID: 8666928 Free PMC article.

8

Expression and function of HLA-A2.1 in transgenic mice.

Epstein H, Hardy R, May JS, Johnson MH, Holmes N. Epstein H, et al. Among authors: holmes n. Eur J Immunol. 1989 Sep;19(9):1575-83. doi: 10.1002/eji.1830190909. Eur J Immunol. 1989. PMID: 2676561

9

Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice.

Ogilvy S, Louis-Dit-Sully C, Cooper J, Cassady RL, Alexander DR, Holmes N. Ogilvy S, et al. Among authors: holmes n. J Immunol. 2003 Aug 15;171(4):1792-800. doi: 10.4049/jimmunol.171.4.1792. J Immunol. 2003. PMID: 12902479

10

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.

McNeill L, Salmond RJ, Cooper JC, Carret CK, Cassady-Cain RL, Roche-Molina M, Tandon P, Holmes N, Alexander DR. McNeill L, et al. Among authors: holmes n. Immunity. 2007 Sep;27(3):425-37. doi: 10.1016/j.immuni.2007.07.015. Epub 2007 Aug 23. Immunity. 2007. PMID: 17719247 Free article.

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