Scales SJ - Search Results

1

The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.

Singh J, Wen X, Scales SJ. Singh J, et al. Among authors: scales sj. J Biol Chem. 2015 Dec 4;290(49):29663-75. doi: 10.1074/jbc.M115.665810. Epub 2015 Oct 8. J Biol Chem. 2015. PMID: 26451044 Free PMC article.

2

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates.

Austin CD, Wen X, Gazzard L, Nelson C, Scheller RH, Scales SJ. Austin CD, et al. Among authors: scales sj. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17987-92. doi: 10.1073/pnas.0509035102. Epub 2005 Dec 1. Proc Natl Acad Sci U S A. 2005. PMID: 16322102 Free PMC article.

3

DNA internalized via caveolae requires microtubule-dependent, Rab7-independent transport to the late endocytic pathway for delivery to the nucleus.

Wong AW, Scales SJ, Reilly DE. Wong AW, et al. Among authors: scales sj. J Biol Chem. 2007 Aug 3;282(31):22953-63. doi: 10.1074/jbc.M611015200. Epub 2007 Jun 11. J Biol Chem. 2007. PMID: 17562704 Free article.

4

A paracrine requirement for hedgehog signalling in cancer.

Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ. Yauch RL, et al. Among authors: scales sj. Nature. 2008 Sep 18;455(7211):406-10. doi: 10.1038/nature07275. Epub 2008 Aug 27. Nature. 2008. PMID: 18754008

5

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.

Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ. Tian H, et al. Among authors: scales sj. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4254-9. doi: 10.1073/pnas.0813203106. Epub 2009 Feb 25. Proc Natl Acad Sci U S A. 2009. PMID: 19246386 Free PMC article.

6

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA. Bosanac I, et al. Among authors: scales sj. Nat Struct Mol Biol. 2009 Jul;16(7):691-7. doi: 10.1038/nsmb.1632. Epub 2009 Jun 28. Nat Struct Mol Biol. 2009. PMID: 19561609

7

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS. Endoh-Yamagami S, et al. Among authors: scales sj. Curr Biol. 2009 Aug 11;19(15):1320-6. doi: 10.1016/j.cub.2009.06.046. Epub 2009 Jul 9. Curr Biol. 2009. PMID: 19592253 Free article.

8

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.

Wen X, Lai CK, Evangelista M, Hongo JA, de Sauvage FJ, Scales SJ. Wen X, et al. Among authors: scales sj. Mol Cell Biol. 2010 Apr;30(8):1910-22. doi: 10.1128/MCB.01089-09. Epub 2010 Feb 12. Mol Cell Biol. 2010. PMID: 20154143 Free PMC article.

9

Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.

Maun HR, Wen X, Lingel A, de Sauvage FJ, Lazarus RA, Scales SJ, Hymowitz SG. Maun HR, et al. Among authors: scales sj. J Biol Chem. 2010 Aug 20;285(34):26570-80. doi: 10.1074/jbc.M110.112284. Epub 2010 May 26. J Biol Chem. 2010. PMID: 20504762 Free PMC article.

10

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.

Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK. Mukhopadhyay S, et al. Among authors: scales sj. Genes Dev. 2010 Oct 1;24(19):2180-93. doi: 10.1101/gad.1966210. Genes Dev. 2010. PMID: 20889716 Free PMC article.

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