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A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity.
Moine E, Denevault-Sabourin C, Debierre-Grockiego F, Silpa L, Gorgette O, Barale JC, Jacquiet P, Brossier F, Gueiffier A, Dimier-Poisson I, Enguehard-Gueiffier C. Moine E, et al. Eur J Med Chem. 2015 Jan 7;89:386-400. doi: 10.1016/j.ejmech.2014.10.057. Epub 2014 Oct 22. Eur J Med Chem. 2015. PMID: 25462254
Imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1 decrease the parasite burden in mice with acute toxoplasmosis.
Moine E, Moiré N, Dimier-Poisson I, Brunet K, Couet W, Colas C, Van Langendonck N, Enguehard-Gueiffier C, Gueiffier A, Héraut B, Denevault-Sabourin C, Debierre-Grockiego F. Moine E, et al. Int J Parasitol. 2018 Jun;48(7):561-568. doi: 10.1016/j.ijpara.2017.12.006. Epub 2018 Mar 7. Int J Parasitol. 2018. PMID: 29524527
Design, synthesis, and antiproliferative effect of 2,9-bis[4-(pyridinylalkylaminomethyl)phenyl]-1,10-phenanthroline derivatives on human leukemic cells by targeting G-quadruplex.
Guillon J, Denevault-Sabourin C, Chevret E, Brachet-Botineau M, Milano V, Guédin-Beaurepaire A, Moreau S, Ronga L, Savrimoutou S, Rubio S, Ferrer J, Lamarche J, Mergny JL, Viaud-Massuard MC, Ranz M, Largy E, Gabelica V, Rosu F, Gouilleux F, Desplat V. Guillon J, et al. Among authors: denevault sabourin c. Arch Pharm (Weinheim). 2021 Aug;354(8):e2000450. doi: 10.1002/ardp.202000450. Epub 2021 Apr 14. Arch Pharm (Weinheim). 2021. PMID: 33852185
18 results