Schmitt MW - Search Results

1

The influence of subclonal resistance mutations on targeted cancer therapy.

Schmitt MW, Loeb LA, Salk JJ. Schmitt MW, et al. Nat Rev Clin Oncol. 2016 Jun;13(6):335-47. doi: 10.1038/nrclinonc.2015.175. Epub 2015 Oct 20. Nat Rev Clin Oncol. 2016. PMID: 26483300 Free PMC article. Review.

2

Sequencing small genomic targets with high efficiency and extreme accuracy.

Schmitt MW, Fox EJ, Prindle MJ, Reid-Bayliss KS, True LD, Radich JP, Loeb LA. Schmitt MW, et al. Nat Methods. 2015 May;12(5):423-5. doi: 10.1038/nmeth.3351. Epub 2015 Apr 6. Nat Methods. 2015. PMID: 25849638 Free PMC article.

3

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations.

Salk JJ, Schmitt MW, Loeb LA. Salk JJ, et al. Among authors: schmitt mw. Nat Rev Genet. 2018 May;19(5):269-285. doi: 10.1038/nrg.2017.117. Epub 2018 Mar 26. Nat Rev Genet. 2018. PMID: 29576615 Free PMC article. Review.

4

Detection of ultra-rare mutations by next-generation sequencing.

Schmitt MW, Kennedy SR, Salk JJ, Fox EJ, Hiatt JB, Loeb LA. Schmitt MW, et al. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14508-13. doi: 10.1073/pnas.1208715109. Epub 2012 Aug 1. Proc Natl Acad Sci U S A. 2012. PMID: 22853953 Free PMC article.

5

Implications of genetic heterogeneity in cancer.

Schmitt MW, Prindle MJ, Loeb LA. Schmitt MW, et al. Ann N Y Acad Sci. 2012 Sep;1267:110-6. doi: 10.1111/j.1749-6632.2012.06590.x. Ann N Y Acad Sci. 2012. PMID: 22954224 Free PMC article.

6

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.

Kennedy SR, Salk JJ, Schmitt MW, Loeb LA. Kennedy SR, et al. Among authors: schmitt mw. PLoS Genet. 2013;9(9):e1003794. doi: 10.1371/journal.pgen.1003794. Epub 2013 Sep 26. PLoS Genet. 2013. PMID: 24086148 Free PMC article.

7

Risks of double-counting in deep sequencing.

Schmitt MW, Fox EJ, Salk JJ. Schmitt MW, et al. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1560. doi: 10.1073/pnas.1400941111. Epub 2014 Mar 20. Proc Natl Acad Sci U S A. 2014. PMID: 24706907 Free PMC article. No abstract available.

8

Detecting ultralow-frequency mutations by Duplex Sequencing.

Kennedy SR, Schmitt MW, Fox EJ, Kohrn BF, Salk JJ, Ahn EH, Prindle MJ, Kuong KJ, Shen JC, Risques RA, Loeb LA. Kennedy SR, et al. Among authors: schmitt mw. Nat Protoc. 2014 Nov;9(11):2586-606. doi: 10.1038/nprot.2014.170. Epub 2014 Oct 9. Nat Protoc. 2014. PMID: 25299156 Free PMC article.

9

Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues.

Krimmel JD, Schmitt MW, Harrell MI, Agnew KJ, Kennedy SR, Emond MJ, Loeb LA, Swisher EM, Risques RA. Krimmel JD, et al. Among authors: schmitt mw. Proc Natl Acad Sci U S A. 2016 May 24;113(21):6005-10. doi: 10.1073/pnas.1601311113. Epub 2016 May 5. Proc Natl Acad Sci U S A. 2016. PMID: 27152024 Free PMC article.

10

Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.

Schmitt MW, Pritchard JR, Leighow SM, Aminov BI, Beppu L, Kim DS, Hodgson JG, Rivera VM, Loeb LA, Radich JP. Schmitt MW, et al. Clin Cancer Res. 2018 Nov 1;24(21):5321-5334. doi: 10.1158/1078-0432.CCR-18-0167. Epub 2018 Jul 24. Clin Cancer Res. 2018. PMID: 30042204 Free PMC article.

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