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Page 1
A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation.
Moncunill-Massaguer C, Saura-Esteller J, Pérez-Perarnau A, Palmeri CM, Núñez-Vázquez S, Cosialls AM, González-Gironès DM, Pomares H, Korwitz A, Preciado S, Albericio F, Lavilla R, Pons G, Langer T, Iglesias-Serret D, Gil J. Moncunill-Massaguer C, et al. Among authors: gonzalez girones dm. Oncotarget. 2015 Dec 8;6(39):41750-65. doi: 10.18632/oncotarget.6154. Oncotarget. 2015. PMID: 26497683 Free PMC article.
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
Santidrián AF, González-Gironès DM, Iglesias-Serret D, Coll-Mulet L, Cosialls AM, de Frias M, Campàs C, González-Barca E, Alonso E, Labi V, Viollet B, Benito A, Pons G, Villunger A, Gil J. Santidrián AF, et al. Among authors: gonzalez girones dm. Blood. 2010 Oct 21;116(16):3023-32. doi: 10.1182/blood-2010-05-283960. Epub 2010 Jul 27. Blood. 2010. PMID: 20664053 Free article.
A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins.
Pérez-Perarnau A, Preciado S, Palmeri CM, Moncunill-Massaguer C, Iglesias-Serret D, González-Gironès DM, Miguel M, Karasawa S, Sakamoto S, Cosialls AM, Rubio-Patiño C, Saura-Esteller J, Ramón R, Caja L, Fabregat I, Pons G, Handa H, Albericio F, Gil J, Lavilla R. Pérez-Perarnau A, et al. Among authors: gonzalez girones dm. Angew Chem Int Ed Engl. 2014 Sep 15;53(38):10150-4. doi: 10.1002/anie.201405758. Epub 2014 Sep 5. Angew Chem Int Ed Engl. 2014. PMID: 25196378
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax.
Cosialls AM, Pomares H, Iglesias-Serret D, Saura-Esteller J, Núñez-Vázquez S, González-Gironès DM, de la Banda E, Preciado S, Albericio F, Lavilla R, Pons G, González-Barca EM, Gil J. Cosialls AM, et al. Among authors: gonzalez girones dm. Haematologica. 2017 Sep;102(9):1587-1593. doi: 10.3324/haematol.2016.162958. Epub 2017 Jun 15. Haematologica. 2017. PMID: 28619845 Free PMC article.
Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
de Frias M, Iglesias-Serret D, Cosialls AM, Coll-Mulet L, Santidrián AF, González-Gironès DM, de la Banda E, Pons G, Gil J. de Frias M, et al. Haematologica. 2009 Dec;94(12):1698-707. doi: 10.3324/haematol.2008.004028. Epub 2009 Oct 8. Haematologica. 2009. PMID: 19815839 Free PMC article.
Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells.
Pérez-Perarnau A, Coll-Mulet L, Rubio-Patiño C, Iglesias-Serret D, Cosialls AM, González-Gironès DM, de Frias M, de Sevilla AF, de la Banda E, Pons G, Gil J. Pérez-Perarnau A, et al. Among authors: gonzalez girones dm. Epigenetics. 2011 Oct 1;6(10):1228-35. doi: 10.4161/epi.6.10.17200. Epub 2011 Oct 1. Epigenetics. 2011. PMID: 21931276 Free article.
Glycogen synthase kinase-3β is involved in ligand-dependent activation of transcription and cellular localization of the glucocorticoid receptor.
Rubio-Patiño C, Palmeri CM, Pérez-Perarnau A, Cosialls AM, Moncunill-Massaguer C, González-Gironès DM, Pons-Hernández L, López JM, Ventura F, Gil J, Pons G, Iglesias-Serret D. Rubio-Patiño C, et al. Among authors: gonzalez girones dm. Mol Endocrinol. 2012 Sep;26(9):1508-20. doi: 10.1210/me.2011-1366. Epub 2012 Jul 6. Mol Endocrinol. 2012. PMID: 22771494 Free PMC article.
12 results