Lu D - Search Results

1

Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes.

Lu D, Dopart R, Kendall DA. Lu D, et al. Cell Stress Chaperones. 2016 Jan;21(1):1-7. doi: 10.1007/s12192-015-0653-5. Cell Stress Chaperones. 2016. PMID: 26498013 Free PMC article.

2

(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs.

Mahmoud MM, Olszewska T, Liu H, Shore DM, Hurst DP, Reggio PH, Lu D, Kendall DA. Mahmoud MM, et al. Among authors: lu d. Mol Pharmacol. 2015 Feb;87(2):197-206. doi: 10.1124/mol.114.095471. Epub 2014 Nov 19. Mol Pharmacol. 2015. PMID: 25411367 Free PMC article.

3

Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor.

Qiao CJ, Ali HI, Ahn KH, Kolluru S, Kendall DA, Lu D. Qiao CJ, et al. Among authors: lu d. Eur J Med Chem. 2016 Oct 4;121:517-529. doi: 10.1016/j.ejmech.2016.05.044. Epub 2016 May 24. Eur J Med Chem. 2016. PMID: 27318976 Free PMC article.

4

Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB₁.

Khurana L, Fu BQ, Duddupudi AL, Liao YH, Immadi SS, Kendall DA, Lu D. Khurana L, et al. Among authors: lu d. J Med Chem. 2017 Feb 9;60(3):1089-1104. doi: 10.1021/acs.jmedchem.6b01448. Epub 2017 Jan 19. J Med Chem. 2017. PMID: 28059509 Free PMC article.

5

Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity.

Dopart R, Lu D, Lichtman AH, Kendall DA. Dopart R, et al. Among authors: lu d. Drug Metab Rev. 2018 Feb;50(1):3-13. doi: 10.1080/03602532.2018.1428342. Epub 2018 Jan 21. Drug Metab Rev. 2018. PMID: 29355030 Free PMC article. Review.

6

Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin-Dependent Responses.

Jagla CAD, Scott CE, Tang Y, Qiao C, Mateo-Semidey GE, Yudowski GA, Lu D, Kendall DA. Jagla CAD, et al. Among authors: lu d. Mol Pharmacol. 2019 Jan;95(1):1-10. doi: 10.1124/mol.118.112854. Epub 2018 Oct 15. Mol Pharmacol. 2019. PMID: 30322873 Free PMC article.

7

Translational potential of allosteric modulators targeting the cannabinoid CB₁ receptor.

Lu D, Immadi SS, Wu Z, Kendall DA. Lu D, et al. Acta Pharmacol Sin. 2019 Mar;40(3):324-335. doi: 10.1038/s41401-018-0164-x. Epub 2018 Oct 17. Acta Pharmacol Sin. 2019. PMID: 30333554 Free PMC article. Review.

8

Molecular Mechanism and Cannabinoid Pharmacology.

Schurman LD, Lu D, Kendall DA, Howlett AC, Lichtman AH. Schurman LD, et al. Among authors: lu d. Handb Exp Pharmacol. 2020;258:323-353. doi: 10.1007/164_2019_298. Handb Exp Pharmacol. 2020. PMID: 32236882 Free PMC article.

9

Profiling two indole-2-carboxamides for allosteric modulation of the CB1 receptor.

Ahn KH, Mahmoud MM, Samala S, Lu D, Kendall DA. Ahn KH, et al. Among authors: lu d. J Neurochem. 2013 Mar;124(5):584-9. doi: 10.1111/jnc.12115. Epub 2013 Jan 7. J Neurochem. 2013. PMID: 23205875 Free PMC article.

10

Structure-activity relationship study of indole-2-carboxamides identifies a potent allosteric modulator for the cannabinoid receptor 1 (CB1).

Mahmoud MM, Ali HI, Ahn KH, Damaraju A, Samala S, Pulipati VK, Kolluru S, Kendall DA, Lu D. Mahmoud MM, et al. Among authors: lu d. J Med Chem. 2013 Oct 24;56(20):7965-75. doi: 10.1021/jm4009828. Epub 2013 Oct 7. J Med Chem. 2013. PMID: 24053617 Free PMC article.

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