Hirata Y - Search Results

1

A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson's disease.

Choong CJ, Sasaki T, Hayakawa H, Yasuda T, Baba K, Hirata Y, Uesato S, Mochizuki H. Choong CJ, et al. Among authors: hirata y. Neurobiol Aging. 2016 Jan;37:103-116. doi: 10.1016/j.neurobiolaging.2015.10.001. Epub 2015 Oct 9. Neurobiol Aging. 2016. PMID: 26545632

2

New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group.

Kiyokawa S, Hirata Y, Nagaoka Y, Shibano M, Taniguchi M, Yasuda M, Baba K, Uesato S. Kiyokawa S, et al. Among authors: hirata y. Bioorg Med Chem. 2010 Jun 1;18(11):3925-33. doi: 10.1016/j.bmc.2010.04.033. Epub 2010 Apr 18. Bioorg Med Chem. 2010. PMID: 20452226

3

New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group.

Kawaratani Y, Harada T, Hirata Y, Nagaoka Y, Tanimura S, Shibano M, Taniguchi M, Yasuda M, Baba K, Uesato S. Kawaratani Y, et al. Among authors: hirata y. Bioorg Med Chem. 2011 Jul 1;19(13):3995-4003. doi: 10.1016/j.bmc.2011.05.031. Epub 2011 May 23. Bioorg Med Chem. 2011. PMID: 21664138

4

A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H, Nagaoka Y. Kumagai A, et al. Among authors: hirata y. PLoS One. 2011;6(10):e26148. doi: 10.1371/journal.pone.0026148. Epub 2011 Oct 13. PLoS One. 2011. PMID: 22022544 Free PMC article.

5

Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.

Hirata Y, Hirata M, Kawaratani Y, Shibano M, Taniguchi M, Yasuda M, Ohmomo Y, Nagaoka Y, Baba K, Uesato S. Hirata Y, et al. Among authors: hirata m. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1926-30. doi: 10.1016/j.bmcl.2012.01.053. Epub 2012 Jan 26. Bioorg Med Chem Lett. 2012. PMID: 22321215

6

Synergistic antitumor effect of a combination of paclitaxel and carboplatin with nobiletin from Citrus depressa on non-small-cell lung cancer cell lines.

Uesato S, Yamashita H, Maeda R, Hirata Y, Yamamoto M, Matsue S, Nagaoka Y, Shibano M, Taniguchi M, Baba K, Ju-ichi M. Uesato S, et al. Among authors: hirata y. Planta Med. 2014 Apr;80(6):452-7. doi: 10.1055/s-0034-1368321. Epub 2014 Mar 31. Planta Med. 2014. PMID: 24687742

7

Influence of the carbamate fungicide benomyl on the gene expression and activity of aromatase in the human breast carcinoma cell line MCF-7.

Kawaratani Y, Matsuoka T, Hirata Y, Fukata N, Nagaoka Y, Uesato S. Kawaratani Y, et al. Among authors: hirata y. Environ Toxicol Pharmacol. 2015 Jan;39(1):292-9. doi: 10.1016/j.etap.2014.11.032. Epub 2014 Dec 10. Environ Toxicol Pharmacol. 2015. PMID: 25543211

8

Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities.

Uesato S, Matsuura Y, Matsue S, Sumiyoshi T, Hirata Y, Takemoto S, Kawaratani Y, Yamai Y, Ishida K, Sasaki T, Enari M. Uesato S, et al. Among authors: hirata y. Bioorg Med Chem. 2016 Apr 15;24(8):1919-26. doi: 10.1016/j.bmc.2016.03.021. Epub 2016 Mar 11. Bioorg Med Chem. 2016. PMID: 27010502

9

Potential Application of 5-Aryl-Substituted 2-Aminobenzamide Type of HDAC1/2- Selective Inhibitors to Pharmaceuticals.

Uesato S, Hirata Y, Sasaki T. Uesato S, et al. Among authors: hirata y. Curr Pharm Des. 2017;23(40):6149-6159. doi: 10.2174/1381612822666161208143417. Curr Pharm Des. 2017. PMID: 27928959 Review.

10

New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death.

Hirata Y, Sasaki T, Kanki H, Choong CJ, Nishiyama K, Kubo G, Hotei A, Taniguchi M, Mochizuki H, Uesato S. Hirata Y, et al. Sci Rep. 2018 Jan 23;8(1):1400. doi: 10.1038/s41598-018-19664-9. Sci Rep. 2018. PMID: 29362442 Free PMC article.

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