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The putative lithium-mimetic ebselen reduces impulsivity in rodent models.
Barkus C, Ferland JN, Adams WK, Churchill GC, Cowen PJ, Bannerman DM, Rogers RD, Winstanley CA, Sharp T. Barkus C, et al. Among authors: sharp t. J Psychopharmacol. 2018 Sep;32(9):1018-1026. doi: 10.1177/0269881118784876. Epub 2018 Jul 10. J Psychopharmacol. 2018. PMID: 29986609
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
Masaki C, Sharpley AL, Cooper CM, Godlewska BR, Singh N, Vasudevan SR, Harmer CJ, Churchill GC, Sharp T, Rogers RD, Cowen PJ. Masaki C, et al. Among authors: sharp t. Psychopharmacology (Berl). 2016 Jul;233(14):2655-61. doi: 10.1007/s00213-016-4319-5. Epub 2016 Jun 2. Psychopharmacology (Berl). 2016. PMID: 27256357 Free PMC article. Clinical Trial.
A safe lithium mimetic for bipolar disorder.
Singh N, Halliday AC, Thomas JM, Kuznetsova OV, Baldwin R, Woon EC, Aley PK, Antoniadou I, Sharp T, Vasudevan SR, Churchill GC. Singh N, et al. Among authors: sharp t. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320. Nat Commun. 2013. PMID: 23299882 Free PMC article.
Ebselen has lithium-like effects on central 5-HT2A receptor function.
Antoniadou I, Kouskou M, Arsiwala T, Singh N, Vasudevan SR, Fowler T, Cadirci E, Churchill GC, Sharp T. Antoniadou I, et al. Among authors: sharp t. Br J Pharmacol. 2018 Jul;175(13):2599-2610. doi: 10.1111/bph.14179. Epub 2018 May 22. Br J Pharmacol. 2018. PMID: 29488218 Free PMC article.
5-HT and depression: is the glass half-full?
Sharp T, Cowen PJ. Sharp T, et al. Curr Opin Pharmacol. 2011 Feb;11(1):45-51. doi: 10.1016/j.coph.2011.02.003. Epub 2011 Mar 4. Curr Opin Pharmacol. 2011. PMID: 21377932 Review.
796 results