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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F. Lahouassa H, et al. Nat Immunol. 2012 Feb 12;13(3):223-228. doi: 10.1038/ni.2236. Nat Immunol. 2012. PMID: 22327569 Free PMC article.
HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.
Lahouassa H, Blondot ML, Chauveau L, Chougui G, Morel M, Leduc M, Guillonneau F, Ramirez BC, Schwartz O, Margottin-Goguet F. Lahouassa H, et al. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5311-6. doi: 10.1073/pnas.1600485113. Epub 2016 Apr 25. Proc Natl Acad Sci U S A. 2016. PMID: 27114546 Free PMC article.
HIV-2/SIV viral protein X counteracts HUSH repressor complex.
Chougui G, Munir-Matloob S, Matkovic R, Martin MM, Morel M, Lahouassa H, Leduc M, Ramirez BC, Etienne L, Margottin-Goguet F. Chougui G, et al. Among authors: lahouassa h. Nat Microbiol. 2018 Aug;3(8):891-897. doi: 10.1038/s41564-018-0179-6. Epub 2018 Jun 11. Nat Microbiol. 2018. PMID: 29891865
p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway.
Allouch A, David A, Amie SM, Lahouassa H, Chartier L, Margottin-Goguet F, Barré-Sinoussi F, Kim B, Sáez-Cirión A, Pancino G. Allouch A, et al. Among authors: lahouassa h. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E3997-4006. doi: 10.1073/pnas.1306719110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082141 Free PMC article. Clinical Trial.
17 results