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Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.
Chapman TM, Gillen KJ, Wallace C, Lee MT, Bakrania P, Khurana P, Coombs PJ, Stennett L, Fox S, Bureau EA, Brownlees J, Melton DW, Saxty B. Chapman TM, et al. Among authors: brownlees j. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103. doi: 10.1016/j.bmcl.2015.08.031. Epub 2015 Aug 17. Bioorg Med Chem Lett. 2015. PMID: 26318993
Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.
Cragnaz L, Spinelli G, De Conti L, Bureau EA, Brownlees J, Feiguin F, Romano V, Skoko N, Klima R, Kettleborough CA, Baralle FE, Baralle M. Cragnaz L, et al. Among authors: brownlees j. Neurobiol Dis. 2021 Dec;160:105515. doi: 10.1016/j.nbd.2021.105515. Epub 2021 Sep 24. Neurobiol Dis. 2021. PMID: 34571136 Free article.
Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration.
Obst J, Simon E, Martin-Estebane M, Pipi E, Barkwill LM, Gonzalez-Rivera I, Buchanan F, Prescott AR, Faust D, Fox S, Brownlees J, Taylor D, Perry VH, Nuthall H, Atkinson PJ, Karran E, Routledge C, Gomez-Nicola D. Obst J, et al. Among authors: brownlees j. Front Immunol. 2020 Oct 8;11:579000. doi: 10.3389/fimmu.2020.579000. eCollection 2020. Front Immunol. 2020. PMID: 33162994 Free PMC article.
3D models of neurodegeneration: implementation in drug discovery.
Whitehouse C, Corbett N, Brownlees J. Whitehouse C, et al. Among authors: brownlees j. Trends Pharmacol Sci. 2023 Apr;44(4):208-221. doi: 10.1016/j.tips.2023.01.005. Epub 2023 Feb 22. Trends Pharmacol Sci. 2023. PMID: 36822950 Free article. Review.
29 results