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Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.
Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT. Popov VB, et al. Among authors: bhanot s. FASEB J. 2016 Mar;30(3):1207-17. doi: 10.1096/fj.15-271999. Epub 2015 Dec 7. FASEB J. 2016. PMID: 26644352 Free PMC article.
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI. Choi CS, et al. Among authors: bhanot s. J Biol Chem. 2007 Aug 3;282(31):22678-88. doi: 10.1074/jbc.M704213200. Epub 2007 May 27. J Biol Chem. 2007. PMID: 17526931 Free article.
Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.
Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI. Erion DM, et al. Among authors: bhanot s. Cell Metab. 2009 Dec;10(6):499-506. doi: 10.1016/j.cmet.2009.10.007. Cell Metab. 2009. PMID: 19945407 Free PMC article.
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.
Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, Petersen KF, Cline GW, Samuel VT, Shulman GI. Kumashiro N, et al. Among authors: bhanot s. Hepatology. 2013 May;57(5):1763-72. doi: 10.1002/hep.26170. Epub 2013 Jan 25. Hepatology. 2013. PMID: 23175050 Free PMC article.
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, Manchem VP, Brown JM, Samuel VT, Shulman GI. Cantley JL, et al. Among authors: bhanot s. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1869-74. doi: 10.1073/pnas.1219456110. Epub 2013 Jan 9. Proc Natl Acad Sci U S A. 2013. PMID: 23302688 Free PMC article.
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.
Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, Still CD, Gerhard GS, Petersen KF, Cline GW, Shulman GI, Samuel VT. Kumashiro N, et al. Among authors: bhanot s. Diabetes. 2013 Jul;62(7):2183-94. doi: 10.2337/db12-1311. Epub 2013 Feb 19. Diabetes. 2013. PMID: 23423574 Free PMC article.
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.
Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI. Galbo T, et al. Among authors: bhanot s. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12780-5. doi: 10.1073/pnas.1311176110. Epub 2013 Jul 9. Proc Natl Acad Sci U S A. 2013. PMID: 23840067 Free PMC article.
151 results