Toll L - Search Results

1

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.

Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Houghten RA, et al. Among authors: toll l. ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5. ACS Comb Sci. 2016. PMID: 26651386 Free PMC article.

2

Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors.

Patkar KA, Wu J, Ganno ML, Singh HD, Ross NC, Rasakham K, Toll L, McLaughlin JP. Patkar KA, et al. Among authors: toll l. J Pharmacol Exp Ther. 2013 Sep;346(3):545-54. doi: 10.1124/jpet.113.206086. Epub 2013 Jul 12. J Pharmacol Exp Ther. 2013. PMID: 23853171

3

Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies.

Wu J, Zhang Y, Maida LE, Santos RG, Welmaker GS, LaVoi TM, Nefzi A, Yu Y, Houghten RA, Toll L, Giulianotti MA. Wu J, et al. Among authors: toll l. J Med Chem. 2013 Dec 27;56(24):10103-17. doi: 10.1021/jm401543h. Epub 2013 Dec 12. J Med Chem. 2013. PMID: 24274400 Free PMC article.

4

Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library.

Chang YP, Banerjee J, Dowell C, Wu J, Gyanda R, Houghten RA, Toll L, McIntosh JM, Armishaw CJ. Chang YP, et al. Among authors: toll l. J Med Chem. 2014 Apr 24;57(8):3511-21. doi: 10.1021/jm500183r. Epub 2014 Apr 3. J Med Chem. 2014. PMID: 24649848 Free PMC article.

5

Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.

Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP. Spetea M, et al. Among authors: toll l. Br J Pharmacol. 2017 Aug;174(15):2444-2456. doi: 10.1111/bph.13854. Epub 2017 Jun 27. Br J Pharmacol. 2017. PMID: 28494108 Free PMC article.

6

Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats.

Wu J, Cippitelli A, Zhang Y, Debevec G, Schoch J, Ozawa A, Yu Y, Liu H, Chen W, Houghten RA, Welmaker GS, Giulianotti MA, Toll L. Wu J, et al. Among authors: toll l. J Med Chem. 2017 Dec 28;60(24):10092-10104. doi: 10.1021/acs.jmedchem.7b01250. Epub 2017 Dec 13. J Med Chem. 2017. PMID: 29178785 Free PMC article.

7

Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.

Li Y, Cazares M, Wu J, Houghten RA, Toll L, Dooley C. Li Y, et al. Among authors: toll l. J Med Chem. 2016 Feb 11;59(3):1239-45. doi: 10.1021/acs.jmedchem.5b01899. Epub 2016 Jan 29. J Med Chem. 2016. PMID: 26789491

8

Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?

Madariaga-Mazón A, Marmolejo-Valencia AF, Li Y, Toll L, Houghten RA, Martinez-Mayorga K. Madariaga-Mazón A, et al. Among authors: toll l. Drug Discov Today. 2017 Nov;22(11):1719-1729. doi: 10.1016/j.drudis.2017.07.002. Epub 2017 Jul 22. Drug Discov Today. 2017. PMID: 28743488 Free PMC article. Review.

9

Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.

Dooley CT, Spaeth CG, Berzetei-Gurske IP, Craymer K, Adapa ID, Brandt SR, Houghten RA, Toll L. Dooley CT, et al. Among authors: toll l. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41. J Pharmacol Exp Ther. 1997. PMID: 9353393

10

Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs.

Cippitelli A, Brunori G, Schoch J, Armishaw CJ, Wu J, Zaveri NT, Giulianotti MA, Welmaker GS, Toll L. Cippitelli A, et al. Among authors: toll l. Psychopharmacology (Berl). 2018 Jun;235(6):1745-1757. doi: 10.1007/s00213-018-4883-y. Epub 2018 Mar 23. Psychopharmacology (Berl). 2018. PMID: 29572652 Free PMC article.

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