van Haandel L - Search Results

1

Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.

Brown JT, Abdel-Rahman SM, van Haandel L, Gaedigk A, Lin YS, Leeder JS. Brown JT, et al. Among authors: van haandel l. Clin Pharmacol Ther. 2016 Jun;99(6):642-50. doi: 10.1002/cpt.319. Epub 2016 Jan 12. Clin Pharmacol Ther. 2016. PMID: 26660002 Free PMC article.

2

Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.

Dinh JC, Pearce RE, Van Haandel L, Gaedigk A, Leeder JS. Dinh JC, et al. Among authors: van haandel l. Drug Metab Dispos. 2016 Jul;44(7):1070-9. doi: 10.1124/dmd.116.069518. Epub 2016 Apr 6. Drug Metab Dispos. 2016. PMID: 27052878 Free PMC article.

3

Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics.

Wagner JB, Abdel-Rahman S, Van Haandel L, Gaedigk A, Gaedigk R, Raghuveer G, Kauffman R, Leeder JS. Wagner JB, et al. Among authors: van haandel l. J Clin Pharmacol. 2018 Jun;58(6):823-833. doi: 10.1002/jcph.1080. Epub 2018 Feb 22. J Clin Pharmacol. 2018. PMID: 29469964

4

Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Wagner JB, Abdel-Rahman S, Gaedigk R, Gaedigk A, Raghuveer G, Staggs VS, Kauffman R, Van Haandel L, Leeder JS. Wagner JB, et al. Among authors: van haandel l. Clin Pharmacol Ther. 2019 Jun;105(6):1501-1512. doi: 10.1002/cpt.1330. Epub 2019 Feb 25. Clin Pharmacol Ther. 2019. PMID: 30549267

5

Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.

Funk RS, van Haandel L, Becker ML, Leeder JS. Funk RS, et al. Among authors: van haandel l. J Pharmacol Exp Ther. 2013 Oct;347(1):154-63. doi: 10.1124/jpet.113.206672. Epub 2013 Jul 25. J Pharmacol Exp Ther. 2013. PMID: 23887097 Free PMC article.

6

Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP.

Singh RK, van Haandel L, Heruth DP, Ye SQ, Leeder JS, Becker ML, Funk RS. Singh RK, et al. Among authors: van haandel l. J Pharmacol Exp Ther. 2018 Apr;365(1):96-106. doi: 10.1124/jpet.117.246199. Epub 2018 Feb 2. J Pharmacol Exp Ther. 2018. PMID: 29420256 Free PMC article.

7

Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia.

Wagner JB, Abdel-Rahman S, Gaedigk A, Gaedigk R, Raghuveer G, Staggs VS, Van Haandel L, Leeder JS. Wagner JB, et al. Among authors: van haandel l. Clin Transl Sci. 2020 May;13(3):628-637. doi: 10.1111/cts.12749. Epub 2020 Mar 9. Clin Transl Sci. 2020. PMID: 31981411 Free PMC article.

8

Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations.

Becker ML, van Haandel L, Gaedigk R, Lasky A, Hoeltzel M, Stobaugh J, Leeder JS. Becker ML, et al. Among authors: van haandel l. Arthritis Rheum. 2010 Jun;62(6):1803-12. doi: 10.1002/art.27434. Arthritis Rheum. 2010. PMID: 20191581 Free article.

9

Urinary biomarkers of trimethoprim bioactivation in vivo following therapeutic dosing in children.

van Haandel L, Goldman JL, Pearce RE, Leeder JS. van Haandel L, et al. Chem Res Toxicol. 2014 Feb 17;27(2):211-8. doi: 10.1021/tx4003325. Epub 2014 Jan 13. Chem Res Toxicol. 2014. PMID: 24380396 Clinical Trial.

10

Folate depletion and increased glutamation in juvenile idiopathic arthritis patients treated with methotrexate.

Funk RS, van Haandel L, Leeder JS, Becker ML. Funk RS, et al. Among authors: van haandel l. Arthritis Rheumatol. 2014 Dec;66(12):3476-85. doi: 10.1002/art.38865. Arthritis Rheumatol. 2014. PMID: 25186097 Free PMC article.

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