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Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.
Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Köhler R, Wulff H. Sankaranarayanan A, et al. Among authors: kohler r. Mol Pharmacol. 2009 Feb;75(2):281-95. doi: 10.1124/mol.108.051425. Epub 2008 Oct 27. Mol Pharmacol. 2009. PMID: 18955585 Free PMC article.
Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis.
Lozano-Gerona J, Oliván-Viguera A, Delgado-Wicke P, Singh V, Brown BM, Tapia-Casellas E, Pueyo E, Valero MS, Garcia-Otín ÁL, Giraldo P, Abarca-Lachen E, Surra JC, Osada J, Hamilton KL, Raychaudhuri SP, Marigil M, Juarranz Á, Wulff H, Miura H, Gilaberte Y, Köhler R. Lozano-Gerona J, et al. Among authors: kohler r. PLoS One. 2020 Mar 9;15(3):e0222619. doi: 10.1371/journal.pone.0222619. eCollection 2020. PLoS One. 2020. PMID: 32150577 Free PMC article.
Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels.
Grgic I, Kiss E, Kaistha BP, Busch C, Kloss M, Sautter J, Müller A, Kaistha A, Schmidt C, Raman G, Wulff H, Strutz F, Gröne HJ, Köhler R, Hoyer J. Grgic I, et al. Among authors: kohler r. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14518-23. doi: 10.1073/pnas.0903458106. Epub 2009 Aug 13. Proc Natl Acad Sci U S A. 2009. PMID: 19706538 Free PMC article.
800 results