Myeku N - Search Results

1

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL, Duff KE. Myeku N, et al. Nat Med. 2016 Jan;22(1):46-53. doi: 10.1038/nm.4011. Epub 2015 Dec 21. Nat Med. 2016. PMID: 26692334 Free PMC article.

2

5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy.

Jiang S, Sydney EJ, Runyan AM, Serpe R, Figueroa HY, Yang M, Myeku N. Jiang S, et al. Among authors: myeku n. bioRxiv [Preprint]. 2023 Feb 4:2023.02.03.526871. doi: 10.1101/2023.02.03.526871. bioRxiv. 2023. Update in: Front Cell Neurosci. 2024 Apr 04;18:1338502. doi: 10.3389/fncel.2024.1338502 PMID: 36778352 Free PMC article. Updated. Preprint.

3

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Congdon EE, et al. Among authors: myeku n. Autophagy. 2012 Apr;8(4):609-22. doi: 10.4161/auto.19048. Epub 2012 Apr 1. Autophagy. 2012. PMID: 22361619 Free PMC article.

4

Cilostazol, a phosphodiesterase 3 inhibitor, activates proteasome-mediated proteolysis and attenuates tauopathy and cognitive decline.

Schaler AW, Myeku N. Schaler AW, et al. Among authors: myeku n. Transl Res. 2018 Mar;193:31-41. doi: 10.1016/j.trsl.2017.11.004. Epub 2017 Nov 23. Transl Res. 2018. PMID: 29232559 Free PMC article.

5

Targeting the 26S Proteasome To Protect Against Proteotoxic Diseases.

Myeku N, Duff KE. Myeku N, et al. Trends Mol Med. 2018 Jan;24(1):18-29. doi: 10.1016/j.molmed.2017.11.006. Epub 2017 Dec 9. Trends Mol Med. 2018. PMID: 29233753 Free PMC article. Review.

6

PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.

Schaler AW, Runyan AM, Clelland CL, Sydney EJ, Fowler SL, Figueroa HY, Shioda S, Santa-Maria I, Duff KE, Myeku N. Schaler AW, et al. Among authors: myeku n. Sci Transl Med. 2021 May 26;13(595):eaba7394. doi: 10.1126/scitranslmed.aba7394. Sci Transl Med. 2021. PMID: 34039738 Free PMC article.

7

Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells.

Arnaud LT, Myeku N, Figueiredo-Pereira ME. Arnaud LT, et al. Among authors: myeku n. J Neurochem. 2009 Jul;110(1):328-42. doi: 10.1111/j.1471-4159.2009.06142.x. Epub 2009 May 3. J Neurochem. 2009. PMID: 19457109 Free PMC article.

8

Assessment of proteasome impairment and accumulation/aggregation of ubiquitinated proteins in neuronal cultures.

Myeku N, Metcalfe MJ, Huang Q, Figueiredo-Pereira M. Myeku N, et al. Methods Mol Biol. 2011;793:273-96. doi: 10.1007/978-1-61779-328-8_18. Methods Mol Biol. 2011. PMID: 21913107 Free PMC article.

9

cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons.

Myeku N, Wang H, Figueiredo-Pereira ME. Myeku N, et al. Neurosci Lett. 2012 Oct 11;527(2):126-31. doi: 10.1016/j.neulet.2012.08.051. Epub 2012 Sep 5. Neurosci Lett. 2012. PMID: 22982149 Free PMC article.

10

Noncoding translation mitigation.

Kesner JS, Chen Z, Shi P, Aparicio AO, Murphy MR, Guo Y, Trehan A, Lipponen JE, Recinos Y, Myeku N, Wu X. Kesner JS, et al. Among authors: myeku n. Nature. 2023 May;617(7960):395-402. doi: 10.1038/s41586-023-05946-4. Epub 2023 Apr 12. Nature. 2023. PMID: 37046090 Free PMC article.

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