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A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.
Gill RG, Pagni PP, Kupfer T, Wasserfall CH, Deng S, Posgai A, Manenkova Y, Bel Hani A, Straub L, Bernstein P, Atkinson MA, Herold KC, von Herrath M, Staeva T, Ehlers MR, Nepom GT. Gill RG, et al. Among authors: bel hani a. Diabetes. 2016 May;65(5):1310-6. doi: 10.2337/db15-0492. Epub 2015 Dec 30. Diabetes. 2016. PMID: 26718498 Free PMC article.
Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes.
Van Belle TL, Pagni PP, Liao J, Sachithanantham S, Dave A, Bel Hani A, Manenkova Y, Amirian N, Yang C, Morin B, Zhang H, Campbell IL, von Herrath MG. Van Belle TL, et al. Among authors: bel hani a. J Autoimmun. 2014 Dec;55:24-32. doi: 10.1016/j.jaut.2014.02.002. Epub 2014 Feb 26. J Autoimmun. 2014. PMID: 24582317 Free PMC article.