Lam PC - Search Results

1

Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.

Dong M, Lam PC, Orry A, Sexton PM, Christopoulos A, Abagyan R, Miller LJ. Dong M, et al. Among authors: lam pc. J Biol Chem. 2016 Mar 4;291(10):5172-84. doi: 10.1074/jbc.M115.706010. Epub 2016 Jan 6. J Biol Chem. 2016. PMID: 26740626 Free PMC article.

2

Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction.

Dong M, Ding XQ, Thomas SE, Gao F, Lam PC, Abagyan R, Miller LJ. Dong M, et al. Among authors: lam pc. Biochemistry. 2007 Apr 17;46(15):4522-31. doi: 10.1021/bi0622468. Epub 2007 Mar 24. Biochemistry. 2007. PMID: 17381074 Free PMC article.

3

Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor.

Dong M, Lam PC, Gao F, Hosohata K, Pinon DI, Sexton PM, Abagyan R, Miller LJ. Dong M, et al. Among authors: lam pc. Mol Pharmacol. 2007 Aug;72(2):280-90. doi: 10.1124/mol.107.035402. Epub 2007 May 2. Mol Pharmacol. 2007. PMID: 17475809

4

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.

Harikumar KG, Lam PC, Dong M, Sexton PM, Abagyan R, Miller LJ. Harikumar KG, et al. Among authors: lam pc. J Biol Chem. 2007 Nov 9;282(45):32834-43. doi: 10.1074/jbc.M704563200. Epub 2007 Sep 7. J Biol Chem. 2007. PMID: 17827151 Free article.

5

Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding.

Dong M, Lam PC, Pinon DI, Sexton PM, Abagyan R, Miller LJ. Dong M, et al. Among authors: lam pc. Mol Pharmacol. 2008 Aug;74(2):413-22. doi: 10.1124/mol.108.047209. Epub 2008 May 8. Mol Pharmacol. 2008. PMID: 18467541 Free PMC article.

6

Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor.

Gao F, Harikumar KG, Dong M, Lam PC, Sexton PM, Christopoulos A, Bordner A, Abagyan R, Miller LJ. Gao F, et al. Among authors: lam pc. Mol Pharmacol. 2009 Aug;76(2):264-74. doi: 10.1124/mol.109.055756. Epub 2009 May 8. Mol Pharmacol. 2009. PMID: 19429716 Free PMC article.

7

Elucidation of the molecular basis of cholecystokinin Peptide docking to its receptor using site-specific intrinsic photoaffinity labeling and molecular modeling.

Dong M, Lam PC, Pinon DI, Abagyan R, Miller LJ. Dong M, et al. Among authors: lam pc. Biochemistry. 2009 Jun 16;48(23):5303-12. doi: 10.1021/bi9004705. Biochemistry. 2009. PMID: 19441839 Free PMC article.

8

Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.

Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ. Dong M, et al. Among authors: lam pc. J Biol Chem. 2010 Mar 26;285(13):9919-9931. doi: 10.1074/jbc.M109.089730. Epub 2010 Jan 25. J Biol Chem. 2010. PMID: 20100828 Free PMC article.

9

Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.

Miller LJ, Chen Q, Lam PC, Pinon DI, Sexton PM, Abagyan R, Dong M. Miller LJ, et al. Among authors: lam pc. J Biol Chem. 2011 May 6;286(18):15895-907. doi: 10.1074/jbc.M110.217901. Epub 2011 Mar 16. J Biol Chem. 2011. PMID: 21454562 Free PMC article.

10

Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.

Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ. Dong M, et al. Among authors: lam pc. J Biol Chem. 2011 Jul 8;286(27):23888-99. doi: 10.1074/jbc.M111.245969. Epub 2011 May 12. J Biol Chem. 2011. PMID: 21566140 Free PMC article.

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