Hirokami Y - Search Results

1

Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition.

Li YX, Kinami K, Hirokami Y, Kato A, Su JK, Jia YM, Fleet GW, Yu CY. Li YX, et al. Among authors: hirokami y. Org Biomol Chem. 2016 Feb 21;14(7):2249-63. doi: 10.1039/c5ob02474a. Epub 2016 Jan 21. Org Biomol Chem. 2016. PMID: 26790356

2

Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal α-Glucosidases: Binding Conformation and Interaction for ntSI.

Kato A, Zhang ZL, Wang HY, Jia YM, Yu CY, Kinami K, Hirokami Y, Tsuji Y, Adachi I, Nash RJ, Fleet GW, Koseki J, Nakagome I, Hirono S. Kato A, et al. Among authors: hirokami y. J Org Chem. 2015 May 1;80(9):4501-15. doi: 10.1021/acs.joc.5b00342. Epub 2015 Apr 13. J Org Chem. 2015. PMID: 25843107

3

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

Désiré J, Mondon M, Fontelle N, Nakagawa S, Hirokami Y, Adachi I, Iwaki R, Fleet GW, Alonzi DS, Twigg G, Butters TD, Bertrand J, Cendret V, Becq F, Norez C, Marrot J, Kato A, Blériot Y. Désiré J, et al. Among authors: hirokami y. Org Biomol Chem. 2014 Nov 28;12(44):8977-96. doi: 10.1039/c4ob00325j. Org Biomol Chem. 2014. PMID: 25277226

4

Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors.

Kato A, Hirokami Y, Kinami K, Tsuji Y, Miyawaki S, Adachi I, Hollinshead J, Nash RJ, Kiappes JL, Zitzmann N, Cha JK, Molyneux RJ, Fleet GW, Asano N. Kato A, et al. Among authors: hirokami y. Phytochemistry. 2015 Mar;111:124-31. doi: 10.1016/j.phytochem.2014.12.011. Epub 2015 Jan 9. Phytochemistry. 2015. PMID: 25583438

5

Strategy for designing selective α-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.

Miyawaki S, Hirokami Y, Kinami K, Hoshino M, Minehira D, Miyamoto D, Nash RJ, Fleet GW, Adachi I, Toyooka N, Kato A. Miyawaki S, et al. Among authors: hirokami y. Bioorg Med Chem. 2017 Jan 1;25(1):107-115. doi: 10.1016/j.bmc.2016.10.015. Epub 2016 Oct 15. Bioorg Med Chem. 2017. PMID: 27789075

6

Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.

Natori Y, Sakuma T, Yoshimura Y, Kinami K, Hirokami Y, Sato K, Adachi I, Kato A, Takahata H. Natori Y, et al. Among authors: hirokami y. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3298-301. doi: 10.1016/j.bmcl.2014.06.001. Epub 2014 Jun 11. Bioorg Med Chem Lett. 2014. PMID: 24973028

7

Synthesis and biological evaluation of N-(2-fluorophenyl)-2β-deoxyfuconojirimycin acetamide as a potent inhibitor for α-l-fucosidases.

Kato A, Okaki T, Ifuku S, Sato K, Hirokami Y, Iwaki R, Kamori A, Nakagawa S, Adachi I, Kiria PG, Onomura O, Minato D, Sugimoto K, Matsuya Y, Toyooka N. Kato A, et al. Among authors: hirokami y. Bioorg Med Chem. 2013 Nov 1;21(21):6565-73. doi: 10.1016/j.bmc.2013.08.028. Epub 2013 Aug 24. Bioorg Med Chem. 2013. PMID: 24026016

8

Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases.

Estévez JC, González MA, Villaverde MC, Hirokami Y, Kato A, Sussman F, Reza D, Estévez RJ. Estévez JC, et al. Among authors: hirokami y. Pharmaceuticals (Basel). 2019 Mar 29;12(2):47. doi: 10.3390/ph12020047. Pharmaceuticals (Basel). 2019. PMID: 30934879 Free PMC article.

9

Effects of tacrolimus (FK506) on encephalomyocarditic virus-induced diabetes in mice.

Yama S, Nishioka W, Hirokami Y, Setoguchi R, Takeyama N, Saeki K, Matsumoto Y, Hayashi T, Doi K, Onodera T. Yama S, et al. Among authors: hirokami y. Microbiol Immunol. 2004;48(1):7-13. doi: 10.1111/j.1348-0421.2004.tb03482.x. Microbiol Immunol. 2004. PMID: 14734853 Free article.

10

Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily.

Miyazaki T, Hirokami Y, Matsuhashi N, Takatsuka H, Naito M. Miyazaki T, et al. Among authors: hirokami y. J Exp Med. 1999 Jan 18;189(2):413-22. doi: 10.1084/jem.189.2.413. J Exp Med. 1999. PMID: 9892623 Free PMC article.

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