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A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.
Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, Hutton ML, O'Neill MJ. Ahmed Z, et al. Among authors: hutton ml. Acta Neuropathol. 2014 May;127(5):667-83. doi: 10.1007/s00401-014-1254-6. Epub 2014 Feb 16. Acta Neuropathol. 2014. PMID: 24531916 Free PMC article.
Conformation determines the seeding potencies of native and recombinant Tau aggregates.
Falcon B, Cavallini A, Angers R, Glover S, Murray TK, Barnham L, Jackson S, O'Neill MJ, Isaacs AM, Hutton ML, Szekeres PG, Goedert M, Bose S. Falcon B, et al. Among authors: hutton ml. J Biol Chem. 2015 Jan 9;290(2):1049-65. doi: 10.1074/jbc.M114.589309. Epub 2014 Nov 18. J Biol Chem. 2015. PMID: 25406315 Free PMC article.
An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.
Cavallini A, Brewerton S, Bell A, Sargent S, Glover S, Hardy C, Moore R, Calley J, Ramachandran D, Poidinger M, Karran E, Davies P, Hutton M, Szekeres P, Bose S. Cavallini A, et al. Among authors: hutton m. J Biol Chem. 2013 Aug 9;288(32):23331-47. doi: 10.1074/jbc.M113.463984. Epub 2013 Jun 24. J Biol Chem. 2013. PMID: 23798682 Free PMC article.
Altered Synapse Stability in the Early Stages of Tauopathy.
Jackson JS, Witton J, Johnson JD, Ahmed Z, Ward M, Randall AD, Hutton ML, Isaac JT, O'Neill MJ, Ashby MC. Jackson JS, et al. Among authors: hutton ml. Cell Rep. 2017 Mar 28;18(13):3063-3068. doi: 10.1016/j.celrep.2017.03.013. Cell Rep. 2017. PMID: 28355559 Free PMC article.
Tau: From research to clinical development.
Holtzman DM, Carrillo MC, Hendrix JA, Bain LJ, Catafau AM, Gault LM, Goedert M, Mandelkow E, Mandelkow EM, Miller DS, Ostrowitzki S, Polydoro M, Smith S, Wittmann M, Hutton M. Holtzman DM, et al. Among authors: hutton m. Alzheimers Dement. 2016 Oct;12(10):1033-1039. doi: 10.1016/j.jalz.2016.03.018. Epub 2016 May 4. Alzheimers Dement. 2016. PMID: 27154059 Review.
482 results