Verkman AS - Search Results

1

Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.

Piechowicz KA, Truong EC, Javed KM, Chaney RR, Wu JY, Phuan PW, Verkman AS, Anderson MO. Piechowicz KA, et al. Among authors: verkman as. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1362-8. doi: 10.3109/14756366.2015.1135912. Epub 2016 Jan 22. J Enzyme Inhib Med Chem. 2016. PMID: 26796863 Free PMC article.

2

3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators.

Sammelson RE, Ma T, Galietta LJ, Verkman AS, Kurth MJ. Sammelson RE, et al. Among authors: verkman as. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2509-12. doi: 10.1016/s0960-894x(03)00482-7. Bioorg Med Chem Lett. 2003. PMID: 12852954

3

Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel.

De La Fuente R, Namkung W, Mills A, Verkman AS. De La Fuente R, et al. Among authors: verkman as. Mol Pharmacol. 2008 Mar;73(3):758-68. doi: 10.1124/mol.107.043208. Epub 2007 Dec 14. Mol Pharmacol. 2008. PMID: 18083779

4

Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis.

Sonawane ND, Verkman AS. Sonawane ND, et al. Among authors: verkman as. Bioorg Med Chem. 2008 Sep 1;16(17):8187-95. doi: 10.1016/j.bmc.2008.07.044. Epub 2008 Jul 23. Bioorg Med Chem. 2008. PMID: 18691893 Free PMC article.

5

Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.

Tradtrantip L, Sonawane ND, Namkung W, Verkman AS. Tradtrantip L, et al. Among authors: verkman as. J Med Chem. 2009 Oct 22;52(20):6447-55. doi: 10.1021/jm9009873. J Med Chem. 2009. PMID: 19785436 Free PMC article.

6

Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles.

Ye L, Knapp JM, Sangwung P, Fettinger JC, Verkman AS, Kurth MJ. Ye L, et al. Among authors: verkman as. J Med Chem. 2010 May 13;53(9):3772-81. doi: 10.1021/jm100235h. J Med Chem. 2010. PMID: 20373765 Free PMC article.

7

Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea.

Namkung W, Thiagarajah JR, Phuan PW, Verkman AS. Namkung W, et al. Among authors: verkman as. FASEB J. 2010 Nov;24(11):4178-86. doi: 10.1096/fj.10-160648. Epub 2010 Jun 25. FASEB J. 2010. PMID: 20581223 Free PMC article.

8

TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.

Namkung W, Phuan PW, Verkman AS. Namkung W, et al. Among authors: verkman as. J Biol Chem. 2011 Jan 21;286(3):2365-74. doi: 10.1074/jbc.M110.175109. Epub 2010 Nov 17. J Biol Chem. 2011. PMID: 21084298 Free PMC article.

9

Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease.

Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. Snyder DS, et al. Among authors: verkman as. J Med Chem. 2011 Aug 11;54(15):5468-77. doi: 10.1021/jm200505e. Epub 2011 Jul 12. J Med Chem. 2011. PMID: 21707078 Free PMC article.

10

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.

Namkung W, Yao Z, Finkbeiner WE, Verkman AS. Namkung W, et al. Among authors: verkman as. FASEB J. 2011 Nov;25(11):4048-62. doi: 10.1096/fj.11-191627. Epub 2011 Aug 11. FASEB J. 2011. PMID: 21836025 Free PMC article.

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